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Description
Rat Anti-Mouse CD133 Antibody (S-R696)Product Specification Host Rat Antigen CD133 Synonyms Prominin 1; Antigen AC133 homolog; Prominin like protein 1; Prom; Proml1; Prom1 Location Endoplasmic reticulum, Apical cell membrane Accession O54990 Clone Number S R696 Antibody Type Rat mAb Isotype IgG2a, Application FCM Reactivity Ms Positive Sample C57BL 6 mouse bone marrow Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4
Product Specification
| Host | Rat |
| Antigen | CD133 |
| Synonyms | Prominin-1; Antigen AC133 homolog; Prominin-like protein 1; Prom; Proml1; Prom1 |
| Location | Endoplasmic reticulum, Apical cell membrane |
| Accession | O54990 |
| Clone Number | S-R696 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a, λ |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Ms |
Background
CD133, also known as prominin-1, is a pentaspan transmembrane glycoprotein encoded by the PROM1 gene. It is widely recognized as a biomarker for the isolation and identification of stem cells and cancer stem cells (CSCs) in various tissues and cancers. This 97-kDa protein features five transmembrane domains, with its N-terminus extending into the extracellular space and the C-terminus residing intracellularly. CD133 is predominantly expressed in cellular protrusions and has been associated with tumorigenesis, metastasis, chemotherapy resistance, and poor prognosis in several cancers, including colorectal, liver, and breast cancer. Additionally, CD133+ cells have demonstrated angiogenic potential and may play a role in tumor vascularization. Recent studies also suggest that CD133 could serve as a predictive marker for anti-angiogenic therapies, such as bevacizumab treatment in metastatic colorectal cancer.
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