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Description
Rat Anti-Mouse CD1d Antibody (S-R665)Product Specification Host Rat Antigen CD1d Synonyms Antigen presenting glycoprotein CD1d1; CD1d. 1; Cd1. 1 Location Cell membrane Accession P11609 Clone Number S R665 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rat |
| Antigen | CD1d |
| Synonyms | Antigen-presenting glycoprotein CD1d1; CD1d.1; Cd1.1 |
| Location | Cell membrane |
| Accession | P11609 |
| Clone Number | S-R665 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Ms |
Background
CD1d is a unique member of the group 2 CD1 molecules, structurally related to MHC class I proteins and forming a heterodimer with β-2-microglobulin. It is an antigen-presenting glycoprotein that binds and presents both self and microbial lipid and glycolipid antigens to T cells, particularly Natural Killer T (NKT) cells. CD1d is expressed on various cell types, including hematopoietic cells like macrophages, B cells, and dendritic cells, as well as non-hematopoietic cells such as intestinal epithelial cells. The protein is localized in the cell surface, endoplasmic reticulum, and lysosome. CD1d plays a crucial role in immune responses, including antigen processing and presentation via MHC class Ib, regulation of T cell proliferation, and cytokine production. It is also implicated in various diseases, such as pulmonary tuberculosis, autoimmune diseases, and certain cancers. Additionally, CD1d has been shown to have non-classical roles, such as modulating lipid metabolism in macrophages and providing protective effects in inflammatory bowel disease models.
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