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Description
Pacific Blue Mouse Anti-Rat CD4 Antibody (S-R631)Product Specification Host Mouse Antigen CD4 Synonyms T cell surface glycoprotein CD4; T cell surface antigen T4 Leu 3; W3 25 antigen Location Cell membrane Accession P05540 Clone Number S R631 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample Lewis Rat splenocytes Purification Protein G Concentration 0. 05mg ml Conjugation Pacific Blue Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3%
Product Specification
| Host | Mouse |
| Antigen | CD4 |
| Synonyms | T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; W3/25 antigen |
| Location | Cell membrane |
| Accession | P05540 |
| Clone Number | S-R631 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | Lewis Rat splenocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Pacific Blue |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Rt |
Background
CD4, also known as cluster of differentiation 4, is a glycoprotein expressed on the surface of certain immune cells, particularly helper T cells. It plays a crucial role in the immune system by acting as a co-receptor with the T cell receptor (TCR) to bind to major histocompatibility complex class II (MHC II) molecules on antigen-presenting cells, facilitating the activation and differentiation of T cells. CD4+ T cells, often referred to as helper T cells, are essential for coordinating immune responses. They secrete various cytokines to activate other immune cells like B cells, macrophages, and cytotoxic T cells, and can differentiate into subtypes such as Th1, Th2, Th17, and regulatory T cells, each with specific functions. Additionally, CD4 is significant in medical contexts like HIV infection, where the virus targets CD4+ T cells, leading to a decline in their numbers and compromising immune function.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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