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Description
Rat Anti-Mouse CD198 Antibody (S-R626)Product Specification Host Rat Antigen CD198 Synonyms C C chemokine receptor type 8; C C CKR 8; CC CKR 8; CCR 8; CDw198; Cmkbr8; Ter1; Ccr8 Location Cell membrane Accession P56484 Clone Number S R626 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse thymocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12
Product Specification
| Host | Rat |
| Antigen | CD198 |
| Synonyms | C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CDw198; Cmkbr8; Ter1; Ccr8 |
| Location | Cell membrane |
| Accession | P56484 |
| Clone Number | S-R626 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse thymocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
CD198, also known as C-C chemokine receptor type 8 (CCR8), is a 41 kD G protein-coupled receptor with seven transmembrane regions, belonging to the beta chemokine receptor family. It is expressed by various immune cells, including subsets of thymocytes, Tregs, NKT cells, Th2-polarized cells, macrophages, monocytes, and monocyte-derived dendritic cells. CCR8 plays a role in mediating chemotaxis toward its ligands, such as CCL1 and CCL18, and is involved in the regulation of monocyte chemotaxis and thymic cell apoptosis. Additionally, CCR8 is associated with Th2 lymphocytes and has a role in allergic diseases. It is also considered an alternative coreceptor to CD4 for HIV-1 infection.
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Exchange/Return Notes
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