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Description
FOLR4 His Tag Protein, HumanProduct Specification Species Human Synonyms FOLR4, Folbp3, FR delta, LOC390243 Accession A6ND01 Amino Acid Sequence Gly20 Ser228, with C terminal His Expression System HEK293 Molecular Weight 27 30kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | FOLR4, Folbp3, FR-delta, LOC390243 |
| Accession | A6ND01 |
| Amino Acid Sequence | Gly20-Ser228, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 27-30kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Matsumura et al. (2021) Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats. Front Cell Dev Biol. 9: 810118. 2、Noda et al. (2020) Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice. Proc Natl Acad Sci USA. 117(21): 11493-11502. |
Background
FOLR4, also known as Sperm-egg fusion protein Juno (IZUMO1R) is receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. First, mammalian spermatozoa undergo the acrosome reaction to become fusion-competent. Then, the acrosome-reacted spermatozoa penetrate the zona pellucida and adhere to and finally fuse with the egg plasma membrane. IZUMO1 is the first sperm protein proven to be essential for sperm-egg fusion in mammals. Sperm-oocyte membrane fusion is one of the most important events for fertilization. So far, IZUMO1 and Fertilization Influencing Membrane Protein (FIMP) on the sperm membrane and CD9 and JUNO (IZUMO1R/FOLR4) on the oocyte membrane have been identified as fusion-required proteins. However, the molecular mechanisms for sperm-oocyte fusion are still unclear. Here, we show that testis-enriched genes, sperm-oocyte fusion required 1 (Sof1/Llcfc1/1700034O15Rik), transmembrane protein 95 (Tmem95), and sperm acrosome associated 6 (Spaca6), encode sperm proteins required for sperm-oocyte fusion in mice. These knockout (KO) spermatozoa carry IZUMO1 but cannot fuse with the oocyte plasma membrane, leading to male sterility.
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4.7 ★★★★★
Based on 29 reviews
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Product Reviews
★★★★★ 5
Comfortable and Classic Dress Shoes That Look Great All Day
Size: 12, Color: Cognac
These dress shoes have been a great addition to my wardrobe. Right out of the box, they felt comfortable thanks to the cushioned foam insole. I can wear them for long days at work or events without my feet feeling sore, which is something I really appreciate.
The faux leather upper looks polished and well-made. The cap-toe design and subtle contrast stitching give the shoes a classic, professional appearance that pairs perfectly with dress pants or a suit. They have a clean, timeless style that never feels outdated.
The fit is true to size, and the lace-up closure provides a secure and adjustable fit. I also like the stability of the stacked heel and the non-slip sole, which gives me confidence when walking on different surfaces.
Overall, these shoes deliver both comfort and style. They look sharp, feel supportive, and hold up well with regular use. I am very happy with this purchase and would definitely recommend them to anyone looking for reliable, classic dress shoes.
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Reviewed in the United States on December 18, 2025
★★★★★ 5
Appearance
Size: 8, Color: Tan
Looks better in person
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Reviewed in the United States on May 31, 2026
★★★★★ 5
very good
Size: 7.5, Color: Cognac
veryyyy gooood
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Reviewed in the United States on January 29, 2026
★★★★★ 5
Nice shoes
Size: 9, Color: Cognac
My Husband loves it 😍
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Reviewed in the United States on January 11, 2026
★★★★★ 4
I just need the size 12
Size: 12, Color: Tan
Gm.i made a mistake the first time when I order the size 13. I return it because it was to big .so I reorder a size 12 now am looking at my order they still sending me the same size 13 i will have to return it again because it is to big sorry I dont know what going
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Reviewed in the United States on May 8, 2026