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Description
Biotinylated ICOS/CD278(C136S,C137S) Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms ICOS,CD278,AILIM,Inducible T cell costimulator Accession Q9Y6W8 1 Amino Acid Sequence Glu21 Phe141C136S,C137Swith Fc Tag at the C Terminus Expression System HEK293 Molecular Weight 50 60kDa (Reducing) Purity 95% by SDS PAGE&>80% SEC HPLC Conjugation Biotin Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according
Product Specification
| Species | Human |
| Synonyms | ICOS,CD278,AILIM,Inducible T-cell costimulator |
| Accession | Q9Y6W8-1 |
| Amino Acid Sequence | Glu21-Phe141（C136S,C137S）with Fc Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 50-60kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE&>80% SEC-HPLC |
| Conjugation | Biotin |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Vetter VK, Benoit T, Rahmani-Khajouei S, Bender D, Inauen R, Djerbi N, Zenz T, Bühler MM. Nodal gamma-delta T-cell lymphoma: expression of TFH-markers causing diagnostic difficulties in a newly described entity. Virchows Arch. 2025 Sep 26. |
Background
ICOS, a CD28 family receptor also designated as AILIM/CD278, functions as a crucial immunoregulator. It potently augments T-cell responses against foreign antigens through promoting proliferation, lymphokine secretion, and enhanced cell-cell interactions while facilitating B-cell antibody production. Although not affecting IL-2, ICOS induces IL-10 synthesis and sustains T-cell viability by preventing apoptosis in pre-activated T-cells. Its pivotal role in CD40-mediated immunoglobulin class switching underscores its importance in humoral immunity. Structurally, ICOS forms functionally active homodimers stabilized by disulfide bonds. Collectively, these properties establish ICOS as a master regulator coordinating T-cell activation, B-cell help, and antibody diversification in adaptive immunity.
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