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Description
CDKN2A/p16INK4a Recombinant Rabbit mAb (S-2536-38)Product Specification Host Rabbit Antigen p16INK4a Synonyms Cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase 4 inhibitor A (CDK4I); p16 INK4a (p16 INK4); P16ink4a; Cdkn2a Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession P51480 Clone Number S 2536 38 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms Positive Sample A20 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | p16INK4a |
| Synonyms | Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A (CDK4I); p16-INK4a (p16-INK4); P16ink4a; Cdkn2a |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | P51480 |
| Clone Number | S-2536-38 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms |
| Positive Sample | A20 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Ms |
Background
p16INK4a is a 16 kDa cyclin-dependent kinase inhibitor encoded by the CDKN2A locus on chromosome 9p21 that specifically binds to and inactivates CDK4/6 complexes, thereby preventing phosphorylation of the retinoblastoma protein (pRb) and enforcing a G1 cell-cycle arrest that functions as a critical tumor-suppressive barrier against oncogenic stress; its expression rises sharply with aging and acts as a robust biomarker of cellular senescence across diverse tissues, while its frequent inactivation through deletion, mutation, or promoter hypermethylation is observed in numerous human cancers, underscoring its pivotal role in both aging-related pathophysiology and oncogenesis.
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