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Description
Prolactin R/PRLR His Tag Protein, HumanProduct Specification Species Human Synonyms Prolactin R, PRLR, PRL R Accession P16471 Amino Acid Sequence Gln25 Asp234, with C terminal 8*His QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDGGGSHHHHHHHH Expression System HEK293 Molecular Weight 32 36kDa Purity >95% by SDS PAGE Endotoxin <0.
Product Specification
| Species | Human |
| Synonyms | Prolactin R, PRLR, PRL-R |
| Accession | P16471 |
| Amino Acid Sequence | Gln25-Asp234, with C-terminal 8*His QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 32-36kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Bole-Feysot C. et al. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 19(3): 225-268. |
Background
Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. Knockout prolactin receptor gene (PRL-R) mice are animal models for prolactinomas and PRL acts via autocrine/paracrine inhibiting lactotroph proliferation. Recently, variants of the PRL-R were identified in prolactinoma patients and their frequency was higher compared to individuals from the genomic database. As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. The PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.
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4.6 ★★★★★
Based on 20 reviews
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Product Reviews
★★★★★ 5
A Must-Have for Sensitive Skin
Size: 5 Fl Oz (Pack of 1)
recently tried La Roche-Posay sunscreen and I’m really impressed! 🌞 The texture is lightweight, non-greasy, and absorbs quickly without leaving a white cast, which is a big plus for daily wear. It feels gentle on my skin and doesn’t clog pores, making it perfect for sensitive or acne-prone skin. I also love that it provides strong, broad-spectrum protection while still feeling breathable. Overall, it’s become my go-to sunscreen—I actually enjoy applying it every morning because it feels more like skincare than sunscreen. Definitely worth it!
I would be honored if you would consider me to receive a PR package. I’d love the opportunity to try more of your products and create authentic content that highlights the benefits of La Roche-Posay skincare.
Thank you so much for your time and consideration!
Warm regards,
Andrea Mohanlall
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Reviewed in the United States on September 4, 2025
★★★★★ 5
Goes on smooth with no white cast.
Size: 3 Fl Oz (Pack of 1)
This is excellent and disappears on the skin. Smooth as silk.
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Reviewed in the United States on May 10, 2026
★★★★★ 4
It feels very good on the skin.
Size: 3 Fl Oz (Pack of 1)
I’ve been using this sunscreen for about a week now, and honestly, I’ve liked it even more than I expected. The skin on my face feels much softer and healthier, and one thing I’ve definitely noticed is that my dark circles are gradually looking a bit lighter and less tired. I love it because it doesn’t feel heavy, absorbs quickly, and doesn’t leave a greasy residue.
I also like that it works well under makeup or just on its own for everyday use. For now, I’m giving it 4 stars because I haven’t been using it for very long yet and want to see more results, but so far, I definitely feel a difference in my skin. If I continue to see more positive changes, I’ll come back to update my review.
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Reviewed in the United States on May 30, 2026
★★★★★ 5
Blends nicely, is not greasy.
Size: 5 Fl Oz (Pack of 1)
Light, blends nicely into skin. Does a good job of blocking the sun. I will buy it again before the summer is over.
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Reviewed in the United States on May 21, 2026
★★★★★ 5
Feels like nothing!
Size: 3 Fl Oz (Pack of 1)
Fantastic! I never write reviews but this is incredible. Just as advertised it dries quickly, doesn’t feel oily and doesn’t leave marks. And the coverage is no joke in this AZ sun! Held up during Memorial Day weekend at the pool all day. Excellent all around!
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Reviewed in the United States on May 25, 2026