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Description
Her3 His Tag Protein, MouseProduct Specification Species Mouse Synonyms Her3, ERBB3, LCCS2, MDA BF 1, MGC88033, c erbB3, erbB3 S, p180 ErbB3, p45 sErbB3, p85 sErbB3 Accession Q61526 Amino Acid Sequence Ser20 His641, with C terminal 10*His
Product Specification
| Species | Mouse |
| Synonyms | Her3, ERBB3, LCCS2, MDA-BF-1, MGC88033, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3 |
| Accession | Q61526 |
| Amino Acid Sequence | Ser20-His641, with C-terminal 10*His SEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRFTQLTEILLGGVYIEKNDKLCHMDTIDWRDIVRVPDAEIVVKNNGGNCPPCHEVCKGRCWGPGPEDCQILTKTICAPQCNGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRGLCPKACEGTGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVHEAHCFSCHPECQPMEGTSTCNGSGSDACARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCKGPELQDCLGQAEVLMSKPHGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 80-95kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Zhang N. et al. (2016) HER3/ErbB3, an emerging cancer therapeutic target. Acta Biochim Biophys Sin. 48(1): 39-48. |
Background
HER3 is a member of the HER (EGFR/ErbB) receptor family consisting of four closely related type 1 transmembrane receptors (EGFR, HER2, HER3, and HER4). HER receptors are part of a complex signaling network intertwined with the Ras/Raf/MAPK, PI3K/AKT, JAK/STAT, and PKC signaling pathways. Aberrant activation of the HER receptors and downstream signaling molecules tips the balance on cellular events, leading to various types of cancers. The HER3 protein is expressed in several types of tumors. That fact, together with the role of HER3 in promoting cell proliferation, implicate that targeting HER3 may have therapeutic relevance. Furthermore, expression and activation of HER3 has been linked to resistance to drugs that target other HER receptors such as agents that act on EGFR or HER2.
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4.2 ★★★★★
Based on 29 reviews
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Product Reviews
★★★★★ 5
My favorite baby book
Format: Board book
This is my absolute favorite book to read to my little one. It's so beautifully written and illustrated. I gift this book at baby showers as well!
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Reviewed in the United States on October 19, 2024
★★★★★ 5
This book made me teary eyed
Format: Board book
I got this book for one of my best friends who is having a baby in march. We have been on a few trips out west together hiking and camping, so this book seemed like the perfect gift for her new baby. The words are simple but so touching- I also could just be emotional because I'm so happy for her. Either way, a great book with beautiful artwork and high quality pages. You wont regret getting it!
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Reviewed in the United States on February 13, 2019
★★★★★ 5
Beautiful!
Format: Board book
I got this book for my baby for Valentine’s Day and it’s stunning! The illustrations and colors are beautiful and the story is too. I love it!
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Reviewed in the United States on February 10, 2024
★★★★★ 5
Beautiful
Format: Board book
Such a lovely book for my newborn and I to read together.
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Reviewed in the United States on August 7, 2024
★★★★★ 5
So sweet!
Format: Board book
This book is really sweet and in hormonal postpartum can cause some tears to shed! I love reading this to my kiddos.
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Reviewed in the United States on December 14, 2023