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Description
RSPO2 C-Flag Protein,HumanProduct Specification Species Human Synonyms R spondin 2; RSPO2; Roof plate specific spondin 2; hRspo2; PRO34209 Accession Q6UXX9 Amino Acid Sequence Gln22 Gly205, with a Flag tag at the C terminus Expression System CHO Molecular Weight 22. 3 KDa Purity 95% by SDS PAGE Physical Appearance Lyophilized Powder Storage Buffer Lyophilized from a 0. 2 m filtered solution of PBS, pH7. 4. Reconstitution Always centrifuge tubes before opening. Do not mix by
Product Specification
| Species | Human |
| Synonyms | R-spondin-2; RSPO2; Roof plate-specific spondin-2; hRspo2; PRO34209 |
| Accession | Q6UXX9 |
| Amino Acid Sequence |
Gln22-Gly205, with a Flag tag at the C-terminus
|
| Expression System | CHO |
| Molecular Weight | 22.3 KDa |
| Purity | ＞95% by SDS-PAGE |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Stability & Storage |
|
Background
R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. R-spondins are a family of four matricellular proteins produced by a variety of cell-types. The four R spondin secreted ligands (RSPO1–RSPO4) act via their cognate LGR4, LGR5 and LGR6 receptors to amplify WNT signalling. Rspo2 in FGF pathway regulation in vivo Overexpressed Rspo2 inhibited elongation of Xenopus ectoderm explants and Erk1 activation in response to FGF. R-spondin2 (RSPO2) plays a crucial role in the activation of the WNT/β-catenin pathway and oncogenesis, RSPO2 in GC specimens and cell lines is closely related to tumor invasion and migration and that RSPO2 promotes EMT in gastric cancer cells by activating WNT/β-catenin signaling.
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