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Description
STAT6 His&Strep Tag Protein, HumanProduct Specification Species Human Synonyms STAT6C,STAT6B, interleukin 4 induced,IL 4 STAT,D12S1644 Accession P42226 1 Amino Acid Sequence Met1 Trp847 with His&Strep Tag at the C Terminus Expression System Baculovirus InsectCells Molecular Weight 95 110kDa (Reducing) Purity 95% by SDS PAGE & > 90% SEC HPLC Conjugation Unconjugated Tag His Tag, Strep Tag Physical Appearance Liquid Storage Buffer 50mM Hepes,200mM NaCl,20%Glycerol,1mM DDT Stability &
Product Specification
| Species | Human |
| Synonyms | STAT6C,STAT6B, interleukin-4 induced,IL-4-STAT,D12S1644 |
| Accession | P42226-1 |
| Amino Acid Sequence | Met1-Trp847 with His&Strep Tag at the C-Terminus |
| Expression System | Baculovirus-InsectCells |
| Molecular Weight | 95-110kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 90% SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag, Strep Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 50mM Hepes,200mM NaCl,20%Glycerol,1mM DDT |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Karpathiou G, Papoudou-Bai A, Ferrand E, Dumollard JM, Peoc'h M. STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology. Pathol Res Pract. 2021 Jul;223:153477. |
Background
STAT6 (Signal Transducer and Activator of Transcription 6) is a transcription factor that plays a pivotal role in the cellular response to interleukin-4 (IL-4). It is activated through IL-4-induced tyrosine phosphorylation. Its primary function is to mediate most of IL-4's effects, including promoting cell survival by inducing the expression of the anti-apoptotic gene BCL2L1/BCL-X(L). To activate transcription, STAT6 requires interaction with coactivator proteins like p300 and CBP. A key physiological characteristic is its direct interaction with NF-κB, which underlies the synergistic transcriptional activation observed between the IL-4 and NF-κB signaling pathways. Clinically, its central role in IL-4-mediated responses makes it a molecule of interest in immune-related processes.
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