SKU: 87043073500

Phospho-SMAD1/5 (Ser463/465) Recombinant Rabbit mAb (S-4058)

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Description

Phospho-SMAD1/5 (Ser463/465) Recombinant Rabbit mAb (S-4058)Product Specification Host Rabbit Antigen Phospho SMAD1 (Ser463 465) SMAD5 (Ser463 465) Synonyms Mothers against decapentaplegic homolog 5; MAD homolog 5; Mothers against DPP homolog 5; JV5 1; SMAD family member 5 (SMAD 5; Smad5; hSmad5); MADH5; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4 1; Mad related protein 1; SMAD family member 1 (SMAD 1; Smad1; hSMAD1); Transforming growth factor beta signaling

Product Specification


Host Rabbit
Antigen Phospho-SMAD1 (Ser463/465)/ SMAD5 (Ser463/465)
Synonyms Mothers against decapentaplegic homolog 5; MAD homolog 5; Mothers against DPP homolog 5; JV5-1; SMAD family member 5 (SMAD 5; Smad5; hSmad5); MADH5; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1 (SMAD 1; Smad1; hSMAD1); Transforming growth factor-beta-signaling protein 1 (BSP-1); BSP1; MADH1; MADR1
Location Cytoplasm, Nucleus, Mitochondrion
Accession Q99717、Q15797
Clone Number S-4058
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms
Positive Sample Human BMP2 treated HepG2 cells, Human BMP2 treated MEF cells
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms

Background

Phospho-SMAD1/5 (Ser463/465) is a key activated transcriptional regulator in the Bone Morphogenetic Protein (BMP) signaling pathway. When BMP ligands bind to type I and type II serine/threonine kinase receptors on the cell membrane, the activated receptor complex specifically phosphorylates the serine residues at position 463 (in SMAD1) and 465 (in SMAD5) within the C-terminal SXS motif of SMAD1 or SMAD5 proteins. This phosphorylation event is the central step in SMAD1/5 activation, prompting them to form a heterotrimeric complex with the common mediator SMAD4 and translocate into the nucleus. There, they regulate the transcription of downstream target genes (such as Id1, Id2, etc.), mediating the crucial role of BMP signaling in various biological processes including cell proliferation, differentiation, apoptosis, as well as embryonic development, bone formation, and homeostasis maintenance. The phosphorylation level at this site serves as a classic molecular marker for assessing the activity of the BMP/SMAD pathway.

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SKU: 87043073500

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4.7 ★★★★★
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A
Ariel B.
Lake Worth, US
★★★★★ 4
Heavy linen character, but a beautifully tailored suit!
Color: Beige, Size: 4, Color: Beige, Size: 4
This is a really nice linen suit! The jacket is beautifully made and well-tailored, with a fun speckled texture that has lots of pretty color variation (we ordered the beige). When I placed it side by side with a similar linen suit from another brand, the difference in the linen texture was really noticeable — this had a much stronger linen character that stands out! It has three useful pockets on the outside of the jacket, which is great for little hands. The only downside is that one of the inside pockets is just for show (faux), which was a bit surprising and somewhat disappointing for my little guy. The pants have pockets too, but they aren’t very deep — perfect for small treasures, but not much more. The pants are made from a lighter, thinner single-layer linen compared to the fully lined, double-layer jacket, which makes sense for comfort and easy movement. The pants didn’t come with a front crease ironed in, so you’ll want to press one yourself. The linen did pick up some creases from being folded in the package, but it doesn’t seem quite as wrinkly as some other linen fabrics I’ve tried. Still, like most linen clothes, especially for boys, the pants will need occasional ironing to keep them looking neat and crisp, especially after a day of play and general wear. The structured, lined jacket stays looking smoother and more put-together with less effort. It also came with a bow tie, a neck tie, and a tuxedo-style white shirt as extras. The ties aren’t great quality — they’d work fine for quick photos but probably won’t hold up to much actual wear. The formal white shirt feels a bit funny paired with the casual linen suit, but I don’t mind at all. We already have white shirts that we prefer, so we’ll use those instead. For us, the extras are really just bonus items we won’t plan on using. Overall, it’s a handsome little suit that’s perfect for special occasions like weddings, family photos, or holiday events. My kid looked adorable in it! The stronger linen texture on the jacket gives it a premium feel that I really like. Just be ready for a bit of extra care with the pants to keep everything sharp.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 8, 2026
C
chzgr8er
Draper, US
★★★★★ 5
Great suit set
Color: Light Grey, Size: 4
It is incredibly attractive and includes everything a young child needs for a special occasion. The material is a 75% polyester and 25% linen blend, and the outer fabric feels remarkably smooth. Its unstructured design allows for an attractive, natural drape, and the blend conveniently allows for machine washing at home. As is typical with linen-based materials, the fabric can be naturally stiff and prone to wrinkling, so I recommend ironing or steaming it before use. The lightweight feel makes it an excellent choice for the spring, summer, and fall months. Overall, this suit offers exceptional value for the price.
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Reviewed in the United States on April 12, 2026
B
Verified Purchase
Bridie
Phoenix, US
★★★★★ 5
Samsonite? I was way off!
Size: 8, Color: Light Blue, Size: 8, Color: Light Blue
Linen was a nice enough material and slightly distracted from the dumb&dumber blue motif. The regular suit material would have been a full homage. It is what he wanted so this was a fair compromise. Stats/ he is a size 8 in most brands, 51in and 60lbs. Purchased an 8. A size 7 would have been a better choice and more tailored look but this fit fine in the important places and he has room to grow. Short notice, quick shipping and fair quality for the price. May your Harry Dunne love it as much as mine did.
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Reviewed in the United States on May 8, 2026
M
Verified Purchase
Maria Lopez
Louisville, US
★★★★★ 5
Great price without skipping on quality.
Size: 12, Color: Light Green, Size: 12, Color: Light Green
Perfect for 8th grade dance. This 3 piece suit fit perfectly. It look so sharp for his dance. This would also be nice for a wedding. I plan on getting a few different colors the price makes it affordable but doesn't skip on quality.
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Reviewed in the United States on May 30, 2026
F
Verified Purchase
Fadel Chayeb
Grantham, US
★★★★★ 5
Buena calidad
Size: 12, Color: Beige
Excelente calidad precio valor buen acabado
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 4, 2026

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