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Description
SLC12A2 Recombinant Rabbit mAb (S-2437-30)Product Specification Host Rabbit Antigen SLC12A2 Synonyms Solute carrier family 12 member 2; Basolateral Na K Cl symporter; Bumetanide sensitive sodium (potassium) chloride cotransporter 2 (BSC2); Na K 2Cl cotransporter 1 (hNKCC1); NKCC1 s Immunogen Synthetic Peptide Location Cell membrane Accession P55011 Clone Number S 2437 30 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample MCF7, HT 29, COLO
Product Specification
| Host | Rabbit |
| Antigen | SLC12A2 |
| Synonyms | Solute carrier family 12 member 2; Basolateral Na-K-Cl symporter; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 (BSC2); Na-K-2Cl cotransporter 1 (hNKCC1); NKCC1 s |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P55011 |
| Clone Number | S-2437-30 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | MCF7, HT-29, COLO 205, NIH/3T3, mouse brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu, Ms |
Background
SLC12A2 (solute carrier family 12 member 2), also known as NKCC1 (Na⁺-K⁺-2Cl⁻ cotransporter-1), is a 1,215-residue, bumetanide-sensitive, electromeutral plasma-membrane protein that uses the inward Na⁺ gradient generated by Na⁺/K⁺-ATPase to drive uphill import of K⁺ and Cl⁻ into cells, thereby regulating ionic homeostasis, cell volume, epithelial salt movement, blood pressure, hearing, GABAergic inhibition, and neuronal excitability through dynamic phosphorylation by oxidative-stress-responsive kinases (e.g., SPAK/OSR1) and membrane trafficking in epithelia, neurons, vascular smooth muscle, immune cells, and secretory glands, with pathophysiological relevance to hypertension, deafness, neuropathic pain, and tumor cell proliferation.
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