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Description
FOXA1 Recombinant Rabbit mAb (SDT-2779-17)Product Specification Host Rabbit Antigen FOXA1 Synonyms Hepatocyte nuclear factor 3 alpha; HNF 3 alpha; HNF 3A; Forkhead box protein A1; Transcription factor 3A (TCF 3A); HNF3A; TCF3A Immunogen Recombinant Protein Location Nucleus Accession P55317 Clone Number SDT 2779 17 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF Reactivity Hu, Ms, Rt Positive Sample HepG2, PC 3, LNCaP, MCF7 Purification Protein A Concentration 0. 5 mg
Product Specification
| Host | Rabbit |
| Antigen | FOXA1 |
| Synonyms | Hepatocyte nuclear factor 3-alpha; HNF-3-alpha; HNF-3A; Forkhead box protein A1; Transcription factor 3A (TCF-3A); HNF3A; TCF3A |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | P55317 |
| Clone Number | SDT-2779-17 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HepG2, PC-3, LNCaP, MCF7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu |
| ICC | 1:500 | Hu |
| IF | 1:100 | Hu |
Background
FOXA1, a 46-kDa, 472-aa winged-helix/forkhead DNA-binding pioneer transcription factor, opens compacted chromatin by partial nucleosome unfolding, thereby enabling recruitment of steroid-hormone receptors and lineage-specific transcriptional programs that govern development, differentiation, and adult homeostasis of liver, pancreas, lung, prostate, and breast; in cancer it acts as a context-dependent tumor suppressor or oncogene—most notably driving estrogen-receptor-α (ERα) binding and luminal breast/prostate identity—through genomic rearrangements, hotspot mutations (e.g., R219S/W), or altered protein–protein interactions that reprogram enhancer landscapes, control epithelial–mesenchymal plasticity, and modulate therapeutic response to endocrine agents, making FOXA1 a critical determinant of lineage fidelity, drug sensitivity, and patient prognosis.
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