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Description
U2AF1 Recombinant Rabbit mAb (S-2384)Product Specification Host Rabbit Antigen U2AF1 Synonyms Splicing factor U2AF 35 kDa subunit; U2 auxiliary factor 35 kDa subunit; U2 small nuclear RNA auxiliary factor 1; U2 snRNP auxiliary factor small subunit; U2AF35; U2AFBP Immunogen Synthetic Peptide Location Nucleus Accession Q01081 Clone Number S 2384 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample 293T, Ramos, HeLa, Raji, RAW264. 7,
Product Specification
| Host | Rabbit |
| Antigen | U2AF1 |
| Synonyms | Splicing factor U2AF 35 kDa subunit; U2 auxiliary factor 35 kDa subunit; U2 small nuclear RNA auxiliary factor 1; U2 snRNP auxiliary factor small subunit; U2AF35; U2AFBP |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q01081 |
| Clone Number | S-2384 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | 293T, Ramos, HeLa, Raji, RAW264.7, mouse liver, C6, rat spleen, COS-7 |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
U2AF1 (U2 small nuclear RNA auxiliary factor 1) is an essential 35-kDa splicing factor that binds the AG dinucleotide at the 3' splice-site of pre-mRNAs as part of the U2AF heterodimer with U2AF2, thereby nucleating spliceosome assembly; it contains two zinc-finger RNA-binding domains, an arginine/serine-rich (RS) domain that mediates protein–protein interactions within the spliceosome, and is frequently mutated at hotspot residues S34 and Q157 in myelodysplastic syndromes and other hematologic malignancies, leading to altered splice-site recognition, widespread RNA mis-splicing, dysregulated erythropoiesis, and response to spliceosome-targeted therapies, making U2AF1 a key regulator of both constitutive and alternative splicing with direct clinical relevance in precision oncology.
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