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Description
Atg13 Recombinant Rabbit mAb (S-2534-22)Product Specification Host Rabbit Antigen Atg13 Synonyms Autophagy related protein 13; KIAA0652; ATG13 Immunogen Synthetic Peptide Location Cytoplasm Accession O75143 Clone Number S 2534 22 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HeLa, PANC 1, Jurkat, MCF7, NIH 3T3, mouse brain, PC 12 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Rabbit |
| Antigen | Atg13 |
| Synonyms | Autophagy-related protein 13; KIAA0652; ATG13 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | O75143 |
| Clone Number | S-2534-22 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, PANC-1, Jurkat, MCF7, NIH/3T3, mouse brain, PC-12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
Atg13 is an essential scaffold protein in the autophagy-initiation ULK1 complex, where it links the kinase ULK1 to FIP200 and Atg101 to form a stable platform that integrates nutrient-dependent signals from mTORC1 and AMPK; upon starvation, dephosphorylation of Atg13 releases mTORC1 inhibition, allowing ULK1 to phosphorylate Atg13 itself and other downstream targets to trigger phagophore nucleation, while constitutive phosphorylation of Atg13 under nutrient-rich conditions keeps autophagy suppressed, and mutations or depletion of Atg13 in model organisms cause severe defects in bulk and selective autophagy, underscoring its central role in maintaining cellular homeostasis through dynamic regulation of autophagic flux.
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