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Description
Alexa Fluor® 488 Mouse Anti-Human CD62L Antibody (S-937-77)Product Specification Host Mouse Antigen CD62L Synonyms L selectin; CD62 antigen like family member L; Leukocyte adhesion molecule 1 (LAM 1); Leukocyte surface antigen Leu 8; Leukocyte endothelial cell adhesion molecule 1 (LECAM1); Lymph node homing receptor; LNHR; LYAM1; SELL Immunogen Recombinant Protein Location Cell membrane Accession P14151 Clone Number S 937 77 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample
Product Specification
| Host | Mouse |
| Antigen | CD62L |
| Synonyms | L-selectin; CD62 antigen-like family member L; Leukocyte adhesion molecule 1 (LAM-1); Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1 (LECAM1); Lymph node homing receptor; LNHR; LYAM1; SELL |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P14151 |
| Clone Number | S-937-77 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood lymphocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD62L, also known as L-selectin, is a type I transmembrane glycoprotein and a member of the selectin family of adhesion molecules, primarily expressed on the surface of leukocytes, including T cells, B cells, and natural killer cells. It plays a crucial role in leukocyte homing and migration, facilitating the initial adhesion and rolling of white blood cells on endothelial cells, particularly in lymph nodes and inflamed tissues. CD62L is also a phenotypic marker for central memory T cells, which have a higher expression of this molecule and can rapidly respond to antigen re-exposure. In addition to its role in immune response and memory, CD62L has potential applications in cancer immunotherapy, where its regulation can enhance T cell infiltration into the tumor microenvironment and improve treatment outcomes.
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