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Description
DLX5 Recombinant Rabbit mAb (S-2785-79)Product Specification Host Rabbit Antigen DLX5 Synonyms Homeobox protein DLX 5 Immunogen Synthetic Peptide Location Nucleus Accession P56178 Clone Number S 2785 79 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF Reactivity Hu, Ms, Rt Positive Sample HeLa, U 87 MG, U 2 OS, A549, A375, mouse placenta, rat placenta Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | DLX5 |
| Synonyms | Homeobox protein DLX-5 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P56178 |
| Clone Number | S-2785-79 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, U-87 MG, U-2 OS, A549, A375, mouse placenta, rat placenta |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
| IF | 1:500 | Ms, Rt |
Background
DLX5 is a distal-less homeobox transcription factor essential for embryonic development, particularly in osteogenesis, chondrogenesis, and craniofacial patterning, where it activates Runx2 and Sp7 to drive osteoblast differentiation while also regulating chondrocyte hypertrophy and coupling bone formation to resorption by modulating the RANKL/OPG ratio in mesenchymal cells; it binds the 5'-TAATTA-3' consensus, synergizes with BMP signaling, and its human mutations are linked to split-hand/split-foot malformation, sensorineural hearing loss, and enhanced osteosarcoma progression via NOTCH pathway activation.
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