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Description
Frizzled-4/FZD4 His Tag Protein, HumanProduct Specification Species Human Synonyms hFz4, FzE4, CD344, Frizzled 4, Fz 4, EVR1, CD344, FZD4S, FEVR, GPCR Accession Q9ULV1 Amino Acid Sequence Phe37 Glu180, with C terminal 8*His FGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEEGGGSHHHHHHHH Expression System HEK293 Molecular Weight 20 28kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation
Product Specification
| Species | Human |
| Synonyms | hFz4, FzE4, CD344, Frizzled 4, Fz-4, EVR1, CD344, FZD4S, FEVR, GPCR |
| Accession | Q9ULV1 |
| Amino Acid Sequence | Phe37-Glu180, with C-terminal 8*His FGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEEGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 20-28kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Nallathambi J. et al. (2006) Identification of novel FZD4 mutations in Indian patients with familial exudative vitreoretinopathy. Mol Vis. 12: 1086-1092. 2、Sjöblom T. et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science. 314(5797): 268-274. |
Background
Frizzled-4, designated CD344, is a 7-transmembrane glycoprotein of the Frizzled family within the G-protein coupled receptor superfamily. Frizzled proteins function as receptors for Wnt proteins and can activate canonical Wnt/beta-catenin signaling as well as planar cell polarity and calcium flux pathways. Frizzled-4 is particularly important in angiogenic Wnt pathway signaling. Frizzled4 plays a crucial role in maintaining the integrity of the blood-brain barrier/blood-eye barrier, and regulating the expression of related proteins in the Frizzled4/Norrin pathway can regulate the switching of the blood-brain/blood-eye barrier. Frizzled-4 plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP).
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4.4 ★★★★★
Based on 29 reviews
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Product Reviews
★★★★★ 5
Good buy
Second time purchasing a variant of this item. Of good quality, no accessories were missing, material is very good, true to colour and does not fade easily, fit exact, hence size up if needed.
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Reviewed in the United States on May 7, 2026
★★★★★ 5
Perfect for my son!
Color: Purple, Size: 7 Years, Color: Purple, Size: 7 Years
Loved that the pants were adjustable and it fit my son perfectly and was shipped fast for Halloween! This was cheaper than a Halloween costume but the quality was 10x better than any bulk Halloween costume store !
We did a DIY joker & I absolutely loved how it turned out ! Definitely could use this for a formal event !
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Reviewed in the United States on February 28, 2026
★★★★★ 5
Is a nice formal suit set
The pant was a little bit too long
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Reviewed in the United States on December 26, 2025
★★★★★ 5
Great 4 piece for a wedding!
Color: Black, Size: 12 Years
My so. Is 10 years old but super skinny and super tall. The pants had an adjustable waist which was perfect for me to adjust to his skinny waist. The length was perfect. The material was great and it was well made. The tie was super easy to put on and the vest has an adjustable band on the back. This was perfect for a wedding he was attending. He looked so handsome! Great price too.
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Reviewed in the United States on October 18, 2025
★★★★★ 4
Great suit order well ahead in case need resizing
It great! My son loves suitz , the only reason I took a star is because the pants were past his ankle very short so we ended up have to use other pants. The shirt and vest fitted perfectly!
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Reviewed in the United States on January 22, 2026
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