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Description
FOXL2 Recombinant Rabbit mAb (SDT-557-361)Product Specification Host Rabbit Antigen FOXL2 Synonyms Forkhead box protein L2 Immunogen Synthetic Peptide Location Nucleus Accession P58012 Clone Number SDT 557 361 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF Reactivity Hu, Ms, Rt Positive Sample K562, A549, mouse ovary Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | FOXL2 |
| Synonyms | Forkhead box protein L2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P58012 |
| Clone Number | SDT-557-361 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | K562, A549, mouse ovary |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu, Ms |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
| IF | 1:500 | Ms |
Background
FOXL2 is a winged-helix/forkhead transcription factor encoded on chromosome 3q23 that is indispensable for female sex determination, ovarian somatic-cell differentiation, granulosa-cell function, and eyelid morphogenesis; mutations or deletions in FOXL2 cause blepharophimosis–ptosis–epicanthus inversus syndrome and are pathognomonically associated with adult granulosa-cell tumours, while somatic missense mutations (most prominently C134W) constitutively activate the protein, driving oncogenesis through altered transcriptional programs that maintain granulosa-cell lineage identity and suppress apoptosis, thereby highlighting its dual role as a gatekeeper of ovarian development and a lineage-specific tumour suppressor/oncogene.
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