SKU: 53773124229

CD140b/PDGFRB Fc Chimera Protein, Human

$135.00 $150.00
Save 10%
No.2 Bestseller on sm10m.ch >

Pay in installments of $37.50 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 31 - Sep 5

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

CD140b/PDGFRB Fc Chimera Protein, HumanProduct Specification Species Human Antigen CD140b PDGFRB Synonyms PDGF R beta, PDGFR beta, Beta platelet derived growth factor receptor, Beta type platelet derived growth factor receptor, CD140 antigen like family member B Accession P09619 Amino Acid Sequence Leu33 Val532, with C terminal Human IgG1 Fc

Product Specification


Species Human
Antigen CD140b/PDGFRB
Synonyms PDGF-R-beta, PDGFR-beta, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B
Accession P09619
Amino Acid Sequence

Leu33-Val532, with C-terminal Human IgG1 Fc LVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Expression System HEK293
Molecular Weight 100-123kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Sweeney MD, Ayyadurai S, Zlokovic BV. Pericytes of the neurovascular unit: key functions and signalling pathways. Nat Neurosci 2016; 19: 771-783. 2. Armulik A, Genove G, Mae M, et al. Pericytes regulate the blood-brain barrier. Nature 2010; 468: 557-561. 3. Daneman R, Zhou L, Kebede AA, et al. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 2010; 468: 562-566. 4. Makihara N, Arimura K, Ago T, et al. Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke. Exp Neurol 2015; 264: 127-134. 5. Sakuma R, Kawahara M, Nakano-Doi A, et al. Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke. J Neuroinflammation 2016; 13: 57. 6. Nakamura K, Arimura K, Nishimura A, et al. Possible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke. Brain Res 2016; 1630: 98-108.

Background

Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) is also called PDGF-R-beta and PDGFR, is receptor that binds specifically to PDGFB. PDGFRB is a tyrosine‐kinase receptor for PDGF‐B and PDGF‐D. PDGF-BB secreted by endothelial cells binds to PDGFRB on pericytes, causing the activation of downstream signaling pathways to regulate survival, migration, apoptosis, proliferation, and differentiation. PDGF-BB/PDGFRB signaling is essential for the pericytes-regulated BBB integrity in the stage of development, and adulthood. Furthermore, expression of PDGF-BB/PDGFRB is upregulated in CNS after cerebral ischemia in human and animal models, which is involved in tissue responses especially targeting vascular pericytes. The PDGFRB/EZH2 pathway is critical for promoting cardiomyocyte proliferation and heart regeneration, providing a potential target for cardiac repair.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 53773124229

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.3 ★★★★★
Based on 18 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
R
rover
Pawtucket, US
★★★★★ 5
Well designed portable water flosser that's holding up so far
There are a number of such portable water flossers on Amazon, but this is one of the better ones IMO. The water pressure is adequate, with enough settings to allow you to ramp up (or keep using on a lower setting if desired). One nice feature is that the tank detaches easily and this makes filling under a tap easier than other units which don't have an easily detached tank. The tank shape is also a bit fatter so it's not too long along any one dimension. The tank capacity of 300 ml is adequate for a single use. The standard suite of flosser heads are included - flossing itself, peridontal, and one for braces. The tongue cleaner attachment is also there but I prefer to use a separate tongue cleaner tool. Charging is via USB-C and while the port isn't super water proof, there's no damage to the unit yet. Battery life is typical at about 20-30 days with twice a day usage.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 20, 2024
J
Verified Purchase
Jaci
San Leandro, US
★★★★★ 1
Quit working in a month
Bought one. It quit working. They sent another… it never worked right before finally dying on me the same way. Looks like it’s not even an available product anymore. But if it ever does come back.. don’t buy it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 25, 2025
S
Saul V.
Boise, US
★★★★★ 5
Not what I expected!
I have never used a dental flosser before, and it showed by the mess I made haha. I can say, this isn't for me, but I can see the appeal. It is relatively lightweight and comes with a lot of different attachments. Loading it up with water is easy and doesn't take much effort. I would call this portable, even though it is a little big. I can only stand the "soft mode". If I choose any other, my mouth is overwhelmed. Overall, I would definitely recommend this if you have experience with dental flossers. It was hard to use at first but you get the hang of it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 1, 2024
R
R. Burke
Whiting, US
★★★★★ 1
Reasonable cost dental device (updated review)
I used this device for a few months to provide an accurate review. First off, it works. Fill the bottom end section with water, snap in a tip, switch on and go. Easy to use, and the instruction set is short and simple, the result of a thoughtful adoption process. Very reasonable cost. Several heads are provided for you to select. And there are three settings to use: soft, normal and pulse. I did not find any benefit to the pulse setting as it seemed to cycle the water pressure lower than to normal repeatedly. Several additional items worth mentioning: 1) The water pressure is modest. the lower pressure is made up for in more water delivery. 2) This device consumes water at a rapid pace. What this means is that you will need to either swallow or spill the water out of the side of your mouth at least twice during the 90 second cycle - while the unit is operating. Switch off during the cycle restarts the countdown. Water will accumulate rapidly in your mouth. You need to spill the accumulated water in your mouth with the unit on. If you remove it from your mouth you will have a mess around you. 3) The on-off switch is located on the handle toward the top. You will need to learn to not place your finger over the switch which abruptly shuts the device off. Conversely, if you like to swith off the device during the cycle to neatly spill accumulated water out of your mouth, you may find yourself attempting to find the switch push button without a tactile means of feeling for it. 4) The charge port has a small flexible grommet covering it, which might take a little while to find where it is located. 5) **This is my update from my original posting**: the duration of charge shortened over the last several weeks to the point where with the unit switched on, the lights are on, but the pump no longer works, meaning it died and has been trashed.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 16, 2024
R
Review
Alexandria, US
★★★★★ 4
Decent water flosser.
This water flosser is a handy way to clean your teeth, especially when you're on the go. It's cordless and rechargeable, and it comes with different tips for various needs. The water tank holds enough for a full cleaning, and it doesn't leak. It has multiple settings, from gentle to strong, to get your teeth feeling fresh. While the tips might not be the most durable, and attaching the top can be a bit tricky, it's a great tool for keeping your mouth clean and healthy. It's a good alternative to traditional flossing, helping to remove bits and keep your gums healthy.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 15, 2025

recommand products

Carnelian Drop Earrings
58.00
U Shape Hoop Earrings
14.95
Zodiac Sign Necklace
14.95
Moldavite Necklaces
64.00
Teddy Bear Fidget Ring
18.95