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Description
HLA-G Recombinant Rabbit mAb (S-2711-78)Product Specification Host Rabbit Antigen HLA G Synonyms HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; MHC class I antigen G; HLA 6. 0; HLAG Immunogen Recombinant Protein Location Secreted, Endosome, Cell membrane, Endoplasmic reticulum Accession P17693 Clone Number S 2711 78 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample SK OV 3, U937, Jurkat, JEG 3 Purification Protein A Concentration
Product Specification
| Host | Rabbit |
| Antigen | HLA-G |
| Synonyms | HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; MHC class I antigen G; HLA-6.0; HLAG |
| Immunogen | Recombinant Protein |
| Location | Secreted, Endosome, Cell membrane, Endoplasmic reticulum |
| Accession | P17693 |
| Clone Number | S-2711-78 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | SK-OV-3, U937, Jurkat, JEG-3 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:2000-1:10000 | Hu |
Background
HLA-G (human leukocyte antigen-G) is a non-classical, heavily glycosylated HLA class Ib molecule that is selectively expressed at the maternal-fetal interface (primarily on invading extravillous cytotrophoblasts) and in immune-privileged adult tissues, where it exerts potent tolerogenic functions through interaction with inhibitory receptors (ILT2, ILT4, KIR2DL4) on NK cells, T cells, macrophages and dendritic cells, thereby inhibiting cytotoxicity, proliferation and cytokine production, promoting regulatory T-cell generation, and ultimately contributing to immune evasion by tumors, acceptance of semi-allogeneic fetuses, and survival of transplanted grafts; its surface expression can be generated through alternative splicing of seven reported isoforms (HLA-G1 to -G7), with HLA-G1 being the full-length membrane-bound form that can also be proteolytically cleaved to generate soluble HLA-G5, while the other isoforms are either soluble or anchored via glycolipid, and its expression is tightly regulated by genetically polymorphic 5′-upstream regulatory elements, hypoxia, cytokines (IL-10, IFN-β, GM-CSF), and microRNAs, making HLA-G a key diagnostic, prognostic and therapeutic target in pregnancy complications, transplantation, autoimmunity and cancer.
Shipping Notes
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
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