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Description
Mannose Receptor Recombinant Rabbit mAb， PBS Only (SDT-2206-59)Product Specification Host Rabbit Antigen Mannose Receptor Synonyms Macrophage mannose receptor 1; MMR; C type lectin domain family 13 member D; C type lectin domain family 13 member D like; Human mannose receptor (hMR); Macrophage mannose receptor 1 like protein 1; CD206; CLEC13D; CLEC13DL; MRC1L1; MRC1 Immunogen Synthetic Peptide Location Cell membrane Accession P22897 Clone Number SDT 2206 59 Antibody Type Recombinant mAb Isotype IgG Application
Product Specification
| Host | Rabbit |
| Antigen | Mannose Receptor |
| Synonyms | Macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Human mannose receptor (hMR); Macrophage mannose receptor 1-like protein 1; CD206; CLEC13D; CLEC13DL; MRC1L1; MRC1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P22897 |
| Clone Number | SDT-2206-59 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Predicted Reactivity | Rt |
| Purification | Protein A |
| Concentration | 1mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4°C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:250-1:500 | Hu |
Background
The Mannose Receptor is a type of C-type lectin receptor primarily found on the surface of antigen-presenting cells such as macrophages, dendritic cells, and certain endothelial cells. It plays a crucial role in the immune system by recognizing and binding to mannose-rich glycoconjugates present on the surface of pathogens like bacteria, fungi, and viruses. Once bound, the receptor facilitates the internalization and degradation of these pathogens through endocytosis, thereby helping to clear infections and initiate immune responses. Additionally, it is involved in the clearance of apoptotic cell debris by recognizing and binding to mannose residues on glycoproteins released from dying cells. This receptor is also implicated in various inflammatory and immune-related diseases, making it an important target for therapeutic interventions.
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