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Description
CFTR Recombinant Rabbit mAb ,PBS Only(SDT-2133-154)Product Specification Host Rabbit Antigen CFTR Synonyms Cystic fibrosis transmembrane conductance regulator; ATP binding cassette sub family C member 7; Channel conductance controlling ATPase; cAMP dependent chloride channel; ABCC7 Immunogen Synthetic Peptide Location Cell membrane, Endoplasmic reticulum membrane Accession P13569 Clone Number SDT 2133 154 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Hu Positive Sample Human
Product Specification
| Host | Rabbit |
| Antigen | CFTR |
| Synonyms | Cystic fibrosis transmembrane conductance regulator; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel; ABCC7 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Endoplasmic reticulum membrane |
| Accession | P13569 |
| Clone Number | SDT-2133-154 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Positive Sample | Human pancreas |
| Purification | Protein A |
| Concentration | 1mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:250 | Hu |
Background
The CFTR protein, or cystic fibrosis transmembrane conductance regulator protein, is a crucial membrane protein found primarily in epithelial cells lining various organs such as the lungs, pancreas, and sweat glands. It functions as a chloride channel, regulating the movement of chloride ions across cell membranes to maintain proper fluid balance and mucus consistency. Mutations in the CFTR gene can lead to cystic fibrosis, a genetic disorder characterized by thick, sticky mucus buildup in the lungs and digestive system, causing chronic infections and impaired organ function. The CFTR protein also plays a role in regulating sodium channels and has broader implications for epithelial cell function and ion transport.
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