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Description
CD300e/LMIR6 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CD300LE, CLM2, CMRF35A5, IREM2 Accession Q496F6 Amino Acid Sequence Leu18 Leu169, with C terminal hIgG1 Fc Expression System HEK293 Molecular Weight 55 72kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Human |
| Synonyms | CD300LE, CLM2, CMRF35A5, IREM2 |
| Accession | Q496F6 |
| Amino Acid Sequence | Leu18-Leu169, with C-terminal hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 55-72kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Sara Coletta,Ambra Bertocco.The immune receptor CD300e negatively regulates T cell activation by impairing the STAT1-dependent antigen presentation. Sci Rep. 2020 Oct 5;10(1):16501. |
Background
CD300e, originally termed immune receptor expressed by myeloid cells (IREM)-2, is a glycosylated surface receptor with a single extracellular Ig-like domain, belonging to a family of immune receptors that includes 8 members, either activating or inhibitory, that are expressed on myeloid cells, on lymphoid cells or on both compartments1. Since the ligand of CD300e is still unknown, its function in human cells has been studied by using an agonistic anti-CD300e monoclonal antibody2. The evidence that the engagement of CD300e in human monocytes and myeloid dendritic cells provided the cells with survival signals and triggered the expression of the activation markers and the release of pro-inflammatory cytokines, led to the conclusion that CD300e is an immune-activating receptor2. The presence of a lysine residue in the transmembrane domain suggested that CD300e might associate with an ITAM-containing adaptor molecule.
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