SKU: 64897659155

Mouse Anti-Human TCR α/β Antibody (S-R686)

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Description

Mouse Anti-Human TCR α/β Antibody (S-R686)Product Specification Host Mouse Antigen TCR Synonyms TCR; TCR Location Cell membrane Accession P01848 P01850 Clone Number S R686 Antibody Type Mouse mAb Application FCM Reactivity Hu Positive Sample Human PBMC Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied. Dilution application dilution species FCM 1: 200 Hu

Product Specification


Host Mouse
Antigen TCR α/β
Synonyms α/β TCR; TCR α/β
Location Cell membrane
Accession P01848、 P01850
Clone Number S-R686
Antibody Type Mouse mAb
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
FCM 1:200 Hu

Background

The T cell receptor (TCR) α and β proteins are essential components of the αβ T cell receptor, a heterodimeric surface protein expressed on T lymphocytes that recognizes antigenic peptides presented by major histocompatibility complex (MHC) molecules. The TCR α chain is encoded by the TRAC (T cell receptor alpha constant) and TRAV (T cell receptor alpha variable) genes, while the TCR β chain is encoded by the TRBC (T cell receptor beta constant) and TRBV (T cell receptor beta variable) genes, along with diversity (TRBD) and joining (TRBJ) segments, enabling extensive combinatorial diversity. Structurally, both chains consist of a variable (V) domain responsible for antigen recognition and a constant (C) domain that anchors the receptor to the cell membrane. The TCR αβ heterodimer associates with the CD3 complex (CD3γε, CD3δε, and CD247 ζζ) to form a functional TCR-CD3 signaling unit, which transmits activation signals upon peptide-MHC engagement. TCR β undergoes V(D)J recombination during thymic development, contributing to the receptor's antigen specificity, whereas TCR α lacks a D segment but still undergoes recombination for diversity. Mutations or dysregulation in TCR α/β genes can lead to immune disorders, including T cell malignancies and autoimmune diseases. TCR αβ T cells are critical for adaptive immunity, mediating responses against infections, tumors, and self-antigens in autoimmune conditions.

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SKU: 64897659155

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4.6 ★★★★★
Based on 20 reviews
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Verified Purchase
shaenaj14
West Palm Beach, US
★★★★★ 5
Great chewy!
Flavor Name: Bacon, Size: X-Large
Super durable chew toy! Our 9 month old golden retriever absolutely loves this thing. Even our 13 lbs malshi runs around with it! Great price for how well it’s holding up.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 12, 2026
D
Verified Purchase
Douglas R. Jackson
Lexington, US
★★★★★ 3
Not really what I paid for.
Flavor Name: Bacon, Size: Medium
I have two major chewer dogs, and one of REALLY chews on everything. It’s super difficult not spending an average of $50 every 2-4 months on chew toys because they go through them so fast. When I got my first boy I saw his chewing habits so I looked for a durable chew toy brand. Nylabone was everyone’s favorite so I tried two or three chew toys for him after attempting other brands. He’s six years old and this past Christmas I JUST threw away his very first chew bone. It lasted over 5 years. I was ecstatic after year one! A heavy duty chew toy brand that actually did was promised! Naturally I stuck with Nylabone, never having an issue with any of their toys until this one. Cheeseburger bacon flavored/scented was my go to for this second puppy I just got with the same, if not more, super chewing habits. He loves trying to steal our bacon and burgers so I’m like, “Okay. I’ll try this one.” It arrives, I open it. It smells like freshly burnt rubber from tires and neither of my boys will touch it. I’m also wondering how this can be durable if I can literally bend without trying much. I’m overly concerned with them digesting it and will probably toss it in the trash since my youngest boy has stomach issues already and doesn’t need this thing irritating it. In short, if you think yours will smell like bacon burger go for it. Just make sure your dog isn’t a super canine chewer because I doubt this thing would last an hour with even one of my dogs and that’s if they would actually touch it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 11, 2021
F
Verified Purchase
Frequent Buyer
Bozeman, US
★★★★★ 4
Ok
Flavor Name: Bacon, Size: Medium
Not for powerful chewers. Did not hold up to Corso pup or Belgian Malinois.
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Reviewed in the United States on August 11, 2024
T
Verified Purchase
Tandielion
Whiting, US
★★★★★ 1
None of the dogs are interested
Flavor Name: Bacon, Size: Medium
My Mini Schnauzer wasn’t at all interested, and she usually at least explores a new toy a little. I even tried rubbing food on it. I washed it & gave it to my brother who has a Belgian Malinois (?) & it was a no go. We rescued a Goldendoodle & she won’t even hold it in her mouth if I hand it to her. My guess is that the toy is too heavy & the rubber has an off putting smell. This one got 3 strikes from not very picky dogs.
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Reviewed in the United States on January 21, 2022
D
Verified Purchase
Desert Rat X
New York, US
★★★★★ 5
Great for a medium chewer!
Flavor Name: Bacon, Size: Medium
Bought this for my Standard Poodle. He's a year old, 65 pounds, and loves to chew but doesn't have the jaw strength of some of my previous dogs (I think my pit bull would have destroyed this in short order!). This works well for him; it's his favorite toy for fetching. It bounces in an unpredictable manner when you throw it so he has fun chasing and retrieving it. It is heavy so be careful throwing it in the house! I like these shapes better than balls that will roll far under things and be difficult to retrieve. I don't know that I would leave him alone with it in case he did chew a piece off, but for monitored play I highly recommend. I'll definitely buy more if these ever wear out but I don't see that happening in the near future!
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Reviewed in the United States on January 14, 2018

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