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Description
Human CCL17/TARC Recombinant Mouse mAb (S-3718)Product Specification Host Mouse Antigen CCL17 TARC Clone Number S 3718 Antibody Type Mouse mAb Isotype IgG1 Application ELISA Reactivity Hu Purification Protein G Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied Dilution application dilution species ELISA 1: 5000 1: 10000 Hu
Product Specification
| Host | Mouse |
| Antigen | CCL17/TARC |
| Clone Number | S-3718 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1 |
| Application | ELISA |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ELISA | 1:5000-1:10000 | Hu |
Background
CCL17, also known as Thymus and Activation-Regulated Chemokine (TARC), is a protein that belongs to the C-C chemokine family. It is primarily produced by dendritic cells, endothelial cells, keratinocytes, and fibroblasts, and is highly expressed in the thymus. CCL17 plays a crucial role in immune regulation by recruiting lymphocytes and modulating immune function. It acts as a ligand for the C-C chemokine receptor type 4 (CCR4), which is highly expressed on helper T cells. This chemokine is involved in various biological processes, including T-cell development, trafficking, and activation of mature T cells. Additionally, CCL17 has been implicated in several diseases, such as chronic kidney disease, where it may promote renal fibrosis by inducing epithelial-mesenchymal transition. In the context of cancer, CCL17 can influence the tumor microenvironment by recruiting regulatory T cells and affecting tumor progression.
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