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Description
LCN2/NGAL His Tag, HumanProduct Specification Species Human Antigen LCN2 NGAL Synonyms Lipocalin 2, Oncogene 24p3, LCN2, HNL, NGAL Accession P80188 Amino Acid Sequence Gln21 Gly198, with C terminal 8*His QDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDGGGGSHHHHHHHH Expression System HEK293 Molecular Weight 26 28kDa Purity 95% by SDS PAGE Endotoxin
Product Specification
| Species | Human |
| Antigen | LCN2/NGAL |
| Synonyms | Lipocalin-2, Oncogene 24p3, LCN2, HNL, NGAL |
| Accession | P80188 |
| Amino Acid Sequence | Gln21-Gly198, with C-terminal 8*His QDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDGGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 26-28kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Biomed Pharmacother. 2021 Oct; 142:112002. doi: 10.1016/j.biopha.2021.112002. Epub 2021 Aug 27. |
Background
Lipocalin-2 (LCN-2) is a novel, 198 amino acid adipocytokine also referred to as neutrophil gelatinase-associated lipocalin (NGAL). It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. NGAL, first known as an antibacterial factor of natural immunity, and an acute-phase protein. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e g. breast, stomach, esophagus, brain) in humans. Recent studies have revealed that NGAL plays an important role in the physiopathology of chronic myeloid leukaemia (CML) mediated by BCR-ABL.
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