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Description
TSLP His Tag Protein, HumanProduct Specification Species Human Synonyms Thymic stromal lymphopoietin Accession Q969D9 Amino Acid Sequence Try29 Gln159, with C His tag Expression System HEK293 Molecular Weight Predicted MW: 16. 6 kDa Observed MW: 17 25 kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer 0. 2M PBS, pH7. 4 with 3% trehalose. Reconstitution Reconstitute no more than 1 mg mL
Product Specification
| Species | Human |
| Synonyms | Thymic stromal lymphopoietin |
| Accession | Q969D9 |
| Amino Acid Sequence | Try29-Gln159, with C-His tag |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 16.6 kDa Observed MW: 17-25 kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Thymic stromal lymphopoietin (TSLP) is a cytokine that plays a vital role in the immune system. It was first discovered in the thymus and is mainly produced by stromal cells. TSLP functions as a key mediator in initiating and regulating immune responses. It activates dendritic cells, which then stimulate the differentiation of T helper cells, especially Th2 cells. This leads to the release of various inflammatory cytokines, contributing to the development of allergic and inflammatory diseases. In addition, TSLP is involved in immune responses against certain pathogens. Its dysregulation has been associated with several immune - related disorders, making it an important target for therapeutic interventions in diseases like asthma and atopic dermatitis.
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4.5 ★★★★★
Based on 10 reviews
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Product Reviews
★★★★★ 5
Great results for over a year (as needed).
Size: 200 Count (Pack of 1)
This brand was recommended by a staff member at my local co-op; they generally know a good deal about their products. I've used it for a year and I get great results with the sublingual tablets. They dissolve under my tongue in 10-15 minutes. The orange flavor is nice, but remember to rinse all of the toothpaste from your mouth or it could affect the citrus taste. I have no "next day" sleepiness from these. This dosage is high, so I'd recommend starting at the 1 mg dose and go from there. Amazon offers a great price; I still shop at the co-op for fresh foods and spices, but I'll switch to Amazon for these tablets.
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Reviewed in the United States on December 30, 2014
★★★★★ 5
Source Naturals Melatonin Orange Flavored Chewables
Size: 200 Count (Pack of 1)
This product is used for occcasional sleeplessness.
The product is made by Source Naturals located in Santa Cruz, CA. It contains 5 mg of melatonin and 338 mcg vitamin B6 (from pyridoxal-5).
I ordered this product after viewing a Dr. Oz episode about premenopausal and post menopausal symptoms of sleeplessness.
Melatonin is a neurohormone produced by humans by the pineal gland (cone shaped organ of the brain that secretes the hormone melatonin into the bloodstream. It is one of the endocrine glands and is situated beneath the back part of the corpus callosium). It helps the body to ease into a restful sleep. Melatonin is also a potent antioxidant.
I purchased Source Naturals' Bio Align product NightRest with melatonin multi nutrient and herb complex, but only tried it while I waited for my melatonin to arrive.
When it arrived, I realized I had purchased a similiar product at a cheaper cost than the huge retail whole-food chain.
This is an excellent product and it performs exactly as the manufacturers suggest. However, I find that their NightRest works much quicker. I take one tablet at around 7 p.m. and I'm out by 9:30-10 p.m. I get a peaceful nights sleep, and I sleep through the night. I wake rested and ready to start my day.
Either product would be super. Order according to your needs.
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Reviewed in the United States on October 18, 2011
★★★★★ 5
BEST SLEEP AID EVER!
Size: 200 Count (Pack of 1)
Most nights, I place 1-2 under my tongue, allowing them to dissolve, and fall asleep quickly. Even when I wake up in the middle of the night, I get right back to sleep easily. I usually combine this melatonin with Source Naturals L-Tryptophan too (1-2 at bedtime) with a glass of water, followed by the melatonin under my tongue. GREAT combination for those who have a hard time sleeping at night, or who have a temporary problem that is keeping them awake. Not necessary to use every night, only as needed. The L-Tryptophan can also be taken midday if you are stressed; however, NEVER use either of these products, or this combination of products, if you take prescription antidepressants or sleeping pills. I started using them 20 years ago instead of prescriptions because of the side-effects of drugs....OH, this sublingual melatonin has great flavor too (dissolve this melatonin under the tongue so it delivers directly to the bloodstream) .
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Reviewed in the United States on March 14, 2020
★★★★★ 4
Just have to be careful not to take more than one per night or else wake up feeling like have a hangover
Size: 200 Count (Pack of 1)
Definitely works for me. Just have to be careful not to take more than one per night or else wake up feeling like have a hangover. Works great for me but not as well for my stepmother. She has severe insomnia and has been on sleeping medications for years. She tried taking this to go a more natural route but did not even affect her.
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Reviewed in the United States on January 9, 2018
★★★★★ 5
surprised!
I actually didn't realize I had ordered "time released" version. I thought these were just normal melatonin. But now that I've tried these, I love them so much better than the regular version! Helps me sleep better through the night. No taste, love this brand of Source Naturals.
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Reviewed in the United States on October 17, 2025
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