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Description
Cynomolgus monkey CFB/Complement factor B Protein, His TagProduct Specification Synonyms C3 C5 convertase Accession A0A2K5TZY3 Amino Acid Sequence Protein sequence (A0A2K5TZY3, Thr26 Leu763, with C His Tag)
Product Specification
| Synonyms | C3/C5 convertase |
| Accession | A0A2K5TZY3 |
| Amino Acid Sequence | Protein sequence (A0A2K5TZY3, Thr26-Leu763, with C-His Tag) TPLSSAQPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLQTQDRKTVKKAECRAIRCPRPQDFENGEYRPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSRYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHSPGEQQKRRIILDPSGSMNIYLVLDGSDSIGAGNFTGAKKCLVNLIEKVASYGVKPRYALVTYATYPRIWVKVSDQESSNADWVTKKLSEINYEDHKLKSGTNTKRALQAVYSMMSWPEDIPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPLVDQVNINALASKKDNEQHVFKVKDMENLEDVFFQMIDESQSLSLCGMVWEHTTGTDYHKQPWQAKISVTRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGKKRDLEIEKVLFHPDYNISGKKEAGIPEFYDYDVALIKLKKKLNYDPTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHVNLFQVLPWLKEKLQDEDLGFL |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 84.6 kDa Observed MW: 100 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Complement Factor B is a pivotal zymogen in the alternative pathway of the complement system. This serine protease circulates in plasma and is essential for innate immunity. Its activation occurs when it binds to C3b, forming the C3 convertase (C3bBb) upon cleavage by Factor D. This enzyme complex amplifies the complement response by cleaving more C3, driving opsonization, inflammation, and the formation of the membrane attack complex. Factor B also plays a role in the lectin pathway. As a key regulator, its deficiency or dysfunction is linked to susceptibility to infections and autoimmune diseases like atypical hemolytic uremic syndrome.
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