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Description
EGFRvIII Fc Chimera Protein, HumanProduct Specification Species Human Synonyms EGFRvIII Accession NP_001333870. 1 Amino Acid Sequence Leu25 Ser378, with C terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | EGFRvIII |
| Accession | NP_001333870.1 |
| Amino Acid Sequence | Leu25-Ser378, with C-terminal Human IgG1 Fc LEEKKGNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 80-95kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Gan H. et al. (2013) The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered. FEBS J. 280(21): 5350-5370. |
Background
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2–7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. Despite this, EGFRvIII displays low-level constitutive signaling that is augmented by reduced internalization and downregulation. Aberrant EGFRvIII signaling has been shown to be important in driving tumor progression and often correlates with poor prognosis. It is clear that EGFRvIII is expressed in a considerable proportion of patients with glioblastoma multiforme (GBM). The presence of EGFRvIII in other tumor types, however, remains controversial.
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4.8 ★★★★★
Based on 26 reviews
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Product Reviews
★★★★★ 5
Tray
Color: Beige 1 Pack, Size: 8" x 11" x 1.8", Color: Beige 1 Pack, Size: 8" x 11" x 1.8"
Perfect as small coffee table tray! Nice and elegant looking!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 8, 2026
★★★★★ 4
Nice product
Color: Gray 1 Pack, Size: 8" x 8" x 1.8"
Why did you pick this product vs others?:
Works well and looks good. Not the highest quality but good for the money.
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Reviewed in the United States on July 9, 2025
★★★★★ 5
Fantastic and elegant looking nightstand or bathroom tray
Color: White 1 Pack, Size: 8" x 8" x 1.8"
I absolutely love this nightstand tray! The elegant gold trim gives it a luxurious look that instantly elevates my nightstand decor.
It works perfectly as a perfume or cologne organizer and keeps all my bottles beautifully displayed. I’ve also used one as a dresser organizer countertop to hold jewelry and skincare, and another as a stylish key tray or key holder bowl by the front door.
The quality is excellent and the design is both functional and beautiful. I love it so much, I’ll definitely be buying a few more to stack it up in a couple of my rooms.
Highly recommend!
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Reviewed in the United States on May 3, 2025
★★★★★ 5
Looks expensive
Color: Black 1 Pack, Size: 8" x 11" x 1.8"
I love this tray on my nightstand! It keeps all my little objects together & looks expensive.
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Reviewed in the United States on January 29, 2026
★★★★★ 5
Nice and Elegant.
Size: 7.7" x 7.7" x 1.7", Color: Black (Metal Glided), Size: 7.7" x 7.7" x 1.7", Color: Black (Metal Glided)
Color looks great, material is good quality and fits most of my items. It makes my items look neat and organized. Price is a bit high but worth it in my opinion.
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Reviewed in the United States on January 22, 2026