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Description
MUC18/CD146 His Tag Protein, HumanProduct Specification Species Human Synonyms METCAM, CD146, Melanoma cell adhesion molecule, MCAM, Cell surface glycoprotein MUC18, Gicerin, MUC18, MelCAM, HEMCAM Accession P43121 Amino Acid Sequence Val24 Gly559, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | METCAM, CD146, Melanoma cell adhesion molecule, MCAM, Cell surface glycoprotein MUC18, Gicerin, MUC18, MelCAM, HEMCAM |
| Accession | P43121 |
| Amino Acid Sequence | Val24-Gly559, with C-terminal 10*His VPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 80-100kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Mills L. et al. (2002) Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 62(17): 5106-5114. 2、Taira E. et al. (2004) Characterization of Gicerin/MUC18/CD146 in the rat nervous system. J Cell Physiol. 198(3): 377-387. 3、Fritzsche F R. et al. (2008) CD146 protein in prostate cancer: revisited with two different antibodies. Pathology. 40(5): 457-464. |
Background
CD146 is a cell adhesion molecule expressed on endothelial cells, as well as on other cells such as mesenchymal stem cells and Th17 lymphocytes. This protein also exists in a soluble form, whereby it can be detected in biological fluids, including the serum or the cerebrospinal fluid (CSF). Some studies have highlighted the significance of CD146 and its soluble form in angiogenesis and inflammation, having been shown to contribute to the pathogenesis of many inflammatory autoimmune diseases, such as systemic sclerosis, mellitus diabetes, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis.
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4.6 ★★★★★
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Product Reviews
★★★★★ 5
Great color. Great Price. Easy to install
Display Size: 24 Inches, Size: SE2426H, Style: AMD Freesync
I just needed a replacement monitor for daily desk use and wasn't interested in gaming, etc. so this fit my needs beautifully. The color is great and the picture is crisp. It was a breeze to install. Great, everyday monitor and super size for home office desks where you won't need a theatre sized monitor.
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Reviewed in the United States on May 31, 2026
★★★★★ 5
Easy and good.
Display Size: 24 Inches, Size: SE2426H, Style: AMD Freesync
Easy setup. Good image.
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Reviewed in the United States on May 10, 2026
★★★★★ 5
No frills just high quality display
Display Size: 24 Inches, Size: SE2426H, Style: AMD Freesync
Inexpensive, high quality, no frills. Perfect for home office where you are using for work tasks. For my setup I ditched the stand for vesa mount so I didn’t want to pay for a model with an adjustable stand that I wouldn’t need.
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Reviewed in the United States on June 2, 2026
★★★★★ 5
Good Value!
Display Size: 24 Inches, Size: SE2426H, Style: AMD Freesync
Easy to set up. Clear and colorful. Like it.
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Reviewed in the United States on May 6, 2026
★★★★★ 5
Recommend
Display Size: 24 Inches, Size: SE2426H, Style: AMD Freesync, Display Size: 24 Inches, Size: SE2426H, Style: AMD Freesync
Very good screen, the size is perfect to me, easy to install, i recommend 👌
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Reviewed in the United States on June 2, 2026