SKU: 83017184523

IL-23 R Fc Chimera Protein, Human

$110.25 $122.50
Save 10%
No.2 Bestseller on sm10m.ch >

Pay in installments of $30.62 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 26 - Aug 31

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

IL-23 R Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IBD17,IL 23 receptor Accession Q5VWK5 1 Amino Acid Sequence Gly24 Gly355 with hIgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 90 110kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms IBD17,IL-23 receptor
Accession Q5VWK5-1
Amino Acid Sequence

Gly24-Gly355 with hIgG1 Fc at the C-Terminus
Expression System HEK293
Molecular Weight

90-110kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Benson JM, Sachs CW, Treacy G, Zhou H, Pendley CE, Brodmerkel CM, Shankar G, Mascelli MA. Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab. Nat Biotechnol. 2011 Jul;29(7):615-24.
2.Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, Powrie F, Maloy KJ. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med. 2006 Oct 30;203(11):2473-83.

Background

Interleukin-23 (IL-23) is a heterodimeric cytokine composed of p19 and p40 subunits. Its functional receptor, IL-23R, combines with the IL-12Rβ1 subunit to form a type I cytokine receptor complex. This complex activates the downstream JAK2-STAT3 signaling pathway, regulating the proliferation, differentiation, and secretion of inflammatory factors in immune cells such as T cells and NK cells. It plays a central role in sustaining Th17 cell-mediated inflammatory responses. Clinically, abnormal activation of the IL-23/IL-23R pathway is a key pathogenic mechanism in autoimmune diseases such as psoriasis and inflammatory bowel disease. Additionally, it promotes tumorigenesis within the tumor microenvironment, making it a critical therapeutic target.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 83017184523

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.3 ★★★★★
Based on 17 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
L
Verified Purchase
Luismi
Port Orchard, US
★★★★★ 5
Exelente producto
Exelente se adhiere Mu bien lo recomiendo
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 20, 2026
M
Mother of 2
Massapequa, US
★★★★★ 5
Nice and Snug.
This fits nice and snug in my husband's 2021 Tesla Y. I like the color and how it matches well with the interior of his car. It holds his water bottle really tight. This will be perfect for transporting drinks from take out restaurants, too. I also like how the holder is very easy to clean. There is a little notch too when you need to place your keycard and helps determine the direction to place the cup holder.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 1, 2025
D
Drew
Birmingham, US
★★★★★ 5
Secured my drinks
This fits my new 2025 Tesla model Y perfectly. Gives the extra grip and support needed to keep my drinks upright. Firm plastic material but pliable.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 2, 2025
A
Verified Purchase
AikenSCGuy
Whiting, US
★★★★★ 5
Nice phone holder
This is a great product. I bought a car that had the base installed so I bought one to be able to use it. Holds great!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 2, 2025
X
Verified Purchase
xiTzMoEx
Massapequa, US
★★★★★ 1
Use locktight red or blue
Product comes loose frequently and its extremely annoying to tighten it takes forever
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 4, 2025

recommand products

Bronze Metal Alloy Fidget Spinner | R188 Mute Bearing Hand Spinner for Stress Relief
10.00
Happy Birthday Lashawn v02 - Circle Acrylic Plaque
39.95
ARTORIGIN UV400 Sunglasses | Unisex Fashion Sunglasses
10.00
High Density Gel Ice Cube Squeeze Toy | Decompression Stress Relief Fidget
10.00
Happy Birthday Leonora v02 - Circle Acrylic Plaque
39.95