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Description
IFN-gamma R1/IFNGR1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CD119,CDw119,IFNGR,IFN gamma R1,IMD27A,IMD27B Accession P15260 Amino Acid Sequence Glu18 Gly245 with hIgG1 Fc Tag at the C Terminus Expression System HEK293 Molecular Weight 60 72kDa (Reducing) Purity 95% by SDS PAGE & > 90% SEC HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according
Product Specification
| Species | Human |
| Synonyms | CD119,CDw119,IFNGR,IFN-gamma-R1,IMD27A,IMD27B |
| Accession | P15260 |
| Amino Acid Sequence | Glu18-Gly245 with hIgG1 Fc Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 60-72kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 90% SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Varol SE, Cinar C, Burtecene N, Sahin S, Yildiz M, Barut K, Cokugras H, Firtina S, Kasapcopur O, Kiykim A. Patients With IgA Vasculitis and Kawasaki Disease Show Dysregulated Interferon Signature. Int J Rheum Dis. 2025 Jul;28(7):e70349. |
Background
CD119 (also known as IFNGR1) is the alpha-chain ligand-binding receptor for interferon-gamma, belonging to the type II cytokine receptor family. Its structure comprises two fibronectin type-III domains and two immunoglobulin-like C2-type domains. Together with IFNGR2, it forms a functional heterodimeric receptor, typically with two receptor molecules binding one IFNγ dimer. This receptor mediates signals from interferon-gamma produced by activated T lymphocytes, triggering antiviral activity, inhibition of cell proliferation, and broad immunoregulatory functions in various cell types. Deficiency in its function is associated with certain primary immunodeficiency disorders and holds significant clinical relevance in infection immunity, tumor immunity, and autoimmune diseases.
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