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Description
SKP2 GST Tag Protein, HumanProduct Specification Species Human Synonyms FBXL1 Accession Q13309 Amino Acid Sequence Arg89 Leu424 with GST Tag at the N Terminus Expression System E. coli Molecular Weight 63kDa (Reducing) Purity 95% by SDS PAGE Conjugation Unconjugated Tag GST Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability
Product Specification
| Species | Human |
| Synonyms | FBXL1 |
| Accession | Q13309 |
| Amino Acid Sequence | Arg89-Leu424 with GST Tag at the N-Terminus |
| Expression System | E.coli |
| Molecular Weight | 63kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | GST Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Schulman BA, Carrano AC, Jeffrey PD, et al. Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature. 2000;408(6810):381-386. |
Background
SKP2 (S-phase kinase-associated protein 2) is an F-box-containing substrate-recognition subunit of the SCFSKP2 E3 ubiquitin ligase complex (Cullin-1-SKP1-SKP2-Rbx1). Its N-terminal F-box docks onto SKP1, while C-terminal leucine-rich repeats (LRRs) capture phosphorylated targets. By catalysing K48-linked poly-ubiquitylation, SKP2 drives proteasomal degradation of a panel of tumour suppressors and cell-cycle brakes, including p27Kip1, p21Cip1, p57Kip2, FOXO1, BRCA2 and RASSF1A, thereby promoting G1/S progression, DNA replication and survival signalling.
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