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Description
Histone H3 (tri methyl K9) Recombinant Rabbit mAb (S-3826)Product Specification Host Rabbit Antigen Histone H3 (tri methyl K9) Synonyms H3K9me3 Location Nucleus Accession P68431 Clone Number S 3826 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, NIH 3T, PC 12, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability &
Product Specification
| Host | Rabbit |
| Antigen | Histone H3 (tri methyl K9) |
| Synonyms | H3K9me3 |
| Location | Nucleus |
| Accession | P68431 |
| Clone Number | S-3826 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, NIH/3T, PC-12, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
Background
Histone H3 tri-methylated lysine 9 (H3K9me3) is a crucial epigenetic mark formed by the trimethylation of the ninth lysine residue on the core histone H3. It is widely recognized as a classic hallmark of constitutive heterochromatin. Its primary function is to recruit effector proteins like Heterochromatin Protein 1 (HP1), which subsequently promotes the compaction of chromatin into a dense, transcriptionally silent higher-order structure. This modification plays a key role in maintaining genomic stability by effectively repressing the aberrant expression of repetitive genomic elements, such as transposons and telomeric regions, as well as foreign genes. Furthermore, H3K9me3 is essential for the transcriptional regulation of specific genes, X-chromosome inactivation, and cell fate determination. It is important to note that aberrant distribution of H3K9me3 is closely associated with various diseases, including cancer development, neurodegenerative disorders, and the aging process.
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