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Description
CD3d Recombinant Rabbit mAb (S-R318)Product Specification Host Rabbit Antigen CD3d Synonyms CD3 Delta, T cell surface glycoprotein CD3 delta chain, T cell receptor T3 delta chain, T3D Location Cell membrane Accession P04234 Clone Number S R318 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | CD3d |
| Synonyms | CD3 Delta, T-cell surface glycoprotein CD3 delta chain, T-cell receptor T3 delta chain, T3D |
| Location | Cell membrane |
| Accession | P04234 |
| Clone Number | S-R318 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IP | 1:50 | null |
| IHC-P | 1:250 | null |
| ICC | 1:500 | null |
| ICFCM | 1:500 | null |
Background
CD3D is one of the components of the T-cell receptor (TCR)/CD3 complex and functions in the signal transduction of T-cell activation. A TCR-mediated signal is conducted across the plasmalemma through the CD3 chain upon extracellular binding of the TCR to antigen-presenting cells. All CD3 chains, which include CD3G, CD3D, CD3E, and CD3Z, possess immunoreceptor tyrosine-based stimulation motifs in their cytoplasmic structural domains. These motifs undergo phosphorylation when acted upon by the Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition, CD3D functions in thymocyte differentiation. Thymocytes fail to differentiate appropriately without a functioning TCR/CD3 complex. Moreover, previous studies reported that CD3D could act as a biomarker for cancers.
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