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Description
Biotinylated LAIR1 Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms LAIR1, CD305 Accession Q6GTX8 Amino Acid Sequence Gln22 His163, with C terminal human IgG Fc & Avi Tag
Product Specification
| Species | Human |
| Synonyms | LAIR1, CD305 |
| Accession | Q6GTX8 |
| Amino Acid Sequence | Gln22-His163, with C- terminal human IgG Fc & Avi Tag QEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERESRSTYNDTEDVSQASPSESEARFRIDSVSEGNAGPYRCIYYKPPKWSEQSDYLELLVKETSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEHIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGLNDIFEAQKIEWHE |
| Expression System | HEK293 |
| Molecular Weight | 55-60kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Tag | Human Fc Tag, Avi Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Meyaard L. et al. (2001) The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). J Exp Med. 194(1): 107-112. 2、Xu M. et al. (2000) Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. J Biol Chem. 275(23): 17440-6. |
Background
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a type I glycoprotein of 287 amino acids containing a single extracellular Ig-like domain followed by a stalk region connected to the single transmembrane domain and 2 cytoplasmic immunoreceptor tyrosine-based inhibitory motifs that relay the inhibitory signal. LAIR-1 is expressed on almost all immune cells, including NK cells, T cells, B cells and mono-cytes, monocyte-derived dendritic cells, eosinophils, and basophils and mast cells. LAIR-1 binds both transmembrane and extracellular matrix collagens. The mLAIR-1 gene maps to the proximal end of mouse chromosome 7 in a region syntenic with human chromosome 19q13.4 where the LRC is located. LAIR-1 are involved in controlling the balance of the immune system to prevent improper activation or overactivation, which may result in tissue damage or autoimmune diseases. LAIR1 has been shown to inhibit T and NK cell activation mediated by several activating receptors. Furthermore, it has been shown that LAIR1 can deliver an inhibiting signal on intracellular free calcium concentration and immunoglobulin (Ig) production induced by the engagement of B cell antigen receptors (BCR).
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4.5 ★★★★★
Based on 24 reviews
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Product Reviews
★★★★★ 5
Perfect gift for an electrician
Tough,great size and perfect my husband loves it stays cold for hours worth the money hard to dent or mess up. Great for an electrician
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Reviewed in the United States on December 25, 2025
★★★★★ 5
I loved
Super good, it really keeps the cold well
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Reviewed in the United States on April 14, 2026
★★★★★ 5
Perfect Buy for you Hardworking Man/Women
I’ve bought my husband 3 of these already for work we love them easy to clean super durable perfect for his job. Keeps his coffee nice and hot and his chilled drinks nice and cool! We love it every chance we get we buy another one.
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Reviewed in the United States on January 11, 2026
★★★★★ 4
Doesn’t maintain hot too long.
I love this cup because the material is good for heavy duty jobs like mine. I took off one star because it does keep hot but not for super long, it lasts hot for about 2-3 hours. Other than that it’s easy to wash and the magnet that comes on the cup is super strong which comes in handy for not loosing it. It magnetized on to the cup.
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Reviewed in the United States on October 28, 2025
★★★★★ 5
It's the best.
I'm picky on my coffee cups. Klien though has made a great cup for ones like me who work construction. This tumbler not only keeps your coffee hot, but is tough as hell. I can't count how many times it's fallen, dropped, or accidently kicked and still works like new. The rubber bottom and sides grip great. The magnet is strong and helps with tipping over, or possibly dropping. The locking lid also helps with spills.
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Reviewed in the United States on August 4, 2024