SKU: 77152377152

IL-23 R Fc Chimera Protein, Human

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Description

IL-23 R Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IBD17,IL 23 receptor Accession Q5VWK5 1 Amino Acid Sequence Gly24 Gly355 with hIgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 90 110kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms IBD17,IL-23 receptor
Accession Q5VWK5-1
Amino Acid Sequence

Gly24-Gly355 with hIgG1 Fc at the C-Terminus
Expression System HEK293
Molecular Weight

90-110kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Benson JM, Sachs CW, Treacy G, Zhou H, Pendley CE, Brodmerkel CM, Shankar G, Mascelli MA. Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab. Nat Biotechnol. 2011 Jul;29(7):615-24.
2.Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, Powrie F, Maloy KJ. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med. 2006 Oct 30;203(11):2473-83.

Background

Interleukin-23 (IL-23) is a heterodimeric cytokine composed of p19 and p40 subunits. Its functional receptor, IL-23R, combines with the IL-12Rβ1 subunit to form a type I cytokine receptor complex. This complex activates the downstream JAK2-STAT3 signaling pathway, regulating the proliferation, differentiation, and secretion of inflammatory factors in immune cells such as T cells and NK cells. It plays a central role in sustaining Th17 cell-mediated inflammatory responses. Clinically, abnormal activation of the IL-23/IL-23R pathway is a key pathogenic mechanism in autoimmune diseases such as psoriasis and inflammatory bowel disease. Additionally, it promotes tumorigenesis within the tumor microenvironment, making it a critical therapeutic target.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 77152377152

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4.8 ★★★★★
Based on 14 reviews
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A
Verified Purchase
AuntBerBer83
Los Angeles, US
★★★★★ 3
Small but Functional
Small, but works for what little bit of jewelry I wear!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 12, 2025
N
Verified Purchase
niresha allen
Carnegie, US
★★★★★ 5
Awesome
Organization is good fit for all my jewels
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 26, 2026
S
Verified Purchase
Sophia G
Alexandria, US
★★★★★ 5
finally organized all my jewerly!
Color: Black
This jewelry box completely transformed the way I store and access my accessories. It’s not just functional, it’s genuinely beautiful, with a sleek design that looks great on my dresser. The exterior feels sturdy and well-made, and the interior is soft and luxurious, keeping all my pieces protected and tangle-free. There’s a perfect place for everything: rings, earrings, necklaces, and even watches or bracelets. I especially love the multiple compartments and drawers, which make it easy to separate everyday items from special pieces. No more digging around or untangling chains! The mirror inside is a thoughtful touch, and the box itself feels compact enough for smaller spaces while still holding a surprising amount. It’s one of those things that makes daily routines feel a little more put-together. If you’re looking for a jewelry box that’s practical, elegant, and gift-worthy, this one checks every box. Great for personal use or as a thoughtful present.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 1, 2025
R
Verified Purchase
readingisnotenough
San Leandro, US
★★★★★ 5
Small jewelry box bit potential
Color: Black
Very stable product perfect to have on dresser or travel. Keeps all of my items organized
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Reviewed in the United States on April 19, 2026
H
Verified Purchase
H C
Belleville, US
★★★★★ 5
Prefect Travel Case
Color: Black, Color: Black
I got this for taking my jewelry on the go. I have to say that I was pleasantly surprised by the quality it feels very sturdy. It has several spots to hold jewelry and keep it organized. The outside is textured and it closes with a snap which can be done easily.
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Reviewed in the United States on May 6, 2026

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