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Description
BSCL2/Seipin Recombinant Rabbit mAb (S-1669-135)Product Specification Host Rabbit Antigen BSCL2 Seipin Synonyms Bernardinelli Seip congenital lipodystrophy type 2 protein Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession Q96G97 Clone Number S 1669 135 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample HEK 293, Raji, HeLa, MCF7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Rabbit |
| Antigen | BSCL2/Seipin |
| Synonyms | Bernardinelli-Seip congenital lipodystrophy type 2 protein |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | Q96G97 |
| Clone Number | S-1669-135 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | HEK-293, Raji, HeLa, MCF7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu |
Background
BSCL2/Seipin is an endoplasmic-reticulum-anchored multi-pass transmembrane protein that drives proper lipid-droplet biogenesis by catalyzing the clustering and directed budding of nascent neutral-lipid lenses within the ER membrane, thereby acting as a molecular scaffold that recruits and concentrates diacylglycerol acyltransferase, phosphatidic-acid-metabolizing enzymes and lipin-1 to nascent droplet formation sites, while missense mutations that disrupt its N-glycosylation motif trigger ER stress, ubiquitin–proteasome degradation and conformational seipinopathy leading to congenital generalized lipodystrophy type 2 or dominant motor-neuron degenerations.
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