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Description
Cullin2-RBX1-ElonginB/C-VHL ProteinProduct Specification Species Human Synonyms VHL ELOB ELOC CUL2 RBX1 Complex Amino Acid Sequence His RBX1 (full length), HA Cullin2 (full length), HA ElonginC (full length), ElonginB (full length), VHL (full length) Expression System Sf9 and E. coli Purity 90% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Physical Appearance Liquid Storage Buffer 20mM HEPES, 200mM NaCl, 5% Glycerol, 2mM TCEP, pH 8. 0 Stability & Storage Store at 80C. Avoid
Product Specification
| Species | Human |
| Synonyms | VHL/ELOB/ELOC/CUL2/RBX1 Complex |
| Amino Acid Sequence |
His-RBX1 (full-length),
HA-Cullin2 (full-length),
HA-ElonginC (full-length),
ElonginB (full-length),
VHL (full-length)
|
| Expression System | Sf9 and E. coli |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | 20mM HEPES, 200mM NaCl, 5% Glycerol, 2mM TCEP, pH 8.0 |
| Stability & Storage | Store at -80ºC. Avoid multiple
freeze-thaw cycles. |
Background
VHL (von Hippel-Lindau disease tumor suppressor) is the substrate recognition subunit for an E3 ligase activity that ubiquitinates proteins containing hydroxyproline residues. Targets of VHL include HIF1 alpha, beta 2 adrenergic receptor, ZHX2 and others. In VHL-box E3 Ubiquitin ligases, VHL is bound to a heterodimer complex composed of Elongin B (ELOB) and Elongin C (ELOC) through the "BC-box motif" found in many proteins in the VHL-box and SOCS-box protein families. ELOB/ELOC serves as an adapter between substrate recognition proteins and Cullin-2 (or Cullin-5) and RBX1 to form an active E3 ligase.
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