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Description
M-CSFR His Tag Protein, HumanProduct Specification Species Human Synonyms M CSFR, CD115, FIM2, FMS, CSF1R Accession P07333 Amino Acid Sequence Ile20 Glu512, with C 8*His Expression System HEK293 Molecular Weight 75 90kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.
Product Specification
| Species | Human |
| Synonyms | M-CSFR, CD115, FIM2, FMS, CSF1R |
| Accession | P07333 |
| Amino Acid Sequence | Ile20-Glu512, with C-8*His |
| Expression System | HEK293 |
| Molecular Weight | 75-90kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Sapi E. et al. (1999) The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 220(1): 1-8. 2、Sapi E. (2004) The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp Biol Med (Maywood). 229(1): 1-11. 3、Bonifer C. et al. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 13: 549-560. |
Background
Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the type Ⅲ subfamily of receptor tyrosine kinases. M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. M-CSF receptor is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. M-CSF R engagement is continuously required for macrophage survival and regulates lineage decisions and maturation of monocytes, macrophages, osteoclasts and DC. M-CSF R and integrin alpha v beta 3 share signaling pathways during osteoclastogenesis and deletion of either causes osteopetrosis. In the brain, microglia expressing increased M-CSF R are concentrated with Alzheimers a beta peptide, but their role in pathogenesis is unclear.
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4.5 ★★★★★
Based on 9 reviews
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Product Reviews
★★★★★ 5
Perfect suit for boys
Color: Navy Blue, Size: 12 Years, Color: Navy Blue, Size: 12 Years
So thankful for this! This suit was perfect! My son wore this all night playing and the durability of this fabric is on another level. Wasn't too thick, looked really nice, and fabric was really soft. It also blended really well with the suits from Mens Warehouse.
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Reviewed in the United States on June 2, 2026
★★★★★ 5
Perfect!
Color: Royal Blue, Size: 12 Years, Color: Royal Blue, Size: 12 Years
I was nervous about purchasing something like this at the last minute. But based on the previous reviews I decided to take a chance.
The suit is nice and the material feels really good. Not thin or cheap at all. My son looked so handsome and grown up. He’s on the slim side so he does have extra room but I don’t mind it because he can definitely grow into it. I did purchase a separate tie because I wanted a pattern to complement the blue.
I’d definitely purchase again!
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Reviewed in the United States on April 15, 2026
★★★★★ 4
Big in waist
Color: Grey, Size: 12 Years
Very nice suit, the material was nice. My son is an average build, the suit fit on the length but unfortunately the pants were huge in the waist. Even with the inside waist adjuster and a belt he couldn't wear them. Which was disappointing because overall the rest of the suit was perfect!
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Reviewed in the United States on May 31, 2026
★★★★★ 5
Perfect
Color: Royal Blue, Size: 8 Years
The tops fit perfectly however my 6 year old is very tall and slim so the pants were a little big but at least the adjustable straps on the inside will help..love the color
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Reviewed in the United States on May 5, 2026
★★★★★ 5
Worth the money
Color: Navy Blue, Size: 12 Years, Color: Navy Blue, Size: 12 Years
Came just in time for my son graduation and he was very sharp and handsome
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Reviewed in the United States on May 31, 2026