SKU: 6367119225

FGL1 Fc Chimera Protein, Human

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Description

FGL1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms FGL1, Hepassocin, HP 041, HFREP 1, LFIRE 1 Accession Q08830 Amino Acid Sequence Leu23 Ile312, with N terminal Human IgG1 Fc Expression System HEK293 Molecular Weight 60 66kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure

Product Specification


Species Human
Synonyms FGL1, Hepassocin, HP-041, HFREP-1, LFIRE-1
Accession Q08830
Amino Acid Sequence Leu23-Ile312, with N-terminal Human IgG1 Fc
Expression System HEK293
Molecular Weight 60-66kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.

Reference

1、Wang J. et al. (2019) Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3. Cell. 176: 334–347.

2、Wu H T. et al. (2016) A novel hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 diabetes. Diabetologia. 59: 1732–1742.

3、Demchev V. et al. (2013) Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization. PLoS ONE. 8: e58084.

Background

Hepassocin, also known as Hepatocyte-derived fibrinogen-related protein 1 (HFREP-1) and Fibrinogen-Like Protein 1 (FGL1), is a liver-specific secreted protein belonging to the fibrinogen superfamily whose members share a fibrinogen domain at their C-termini. FGL1 is a 68-KD protein comprised of a disulfide bond-linked homodimer. Its carboxyl terminus contains the β and γ subunits, which are highly homologous to fibrinogen but irrelevant to coagulation-related binding sites. Under normal physiological conditions, FGL1 is secreted mainly by hepatocytes in the liver (some of which may also exist in the pancreas). It is now clear that FGL1 is the product of hepatocyte regeneration and participates in hepatocyte mitosis and liver energy utilization (including lipid metabolism and blood glucose regulation). Apart from the above functions, FGL1 can also be detected in the plasma as an acute reactant, implying that FGL1 secreted by the liver acts not only on hepatocytes (autocrine) but also on other tissues, such as muscle and brown adipose tissues (telecrine). Under stimulation by metabolic factors (hyperglycemia, hyperlipidemia, hormones, etc.), the liver secretes FGL1 and participates in the blood circulation. This function of FGL1 acts on brown adipose tissue, regulates body productivity and maintains body temperature. Moreover, FGL1 also acts on muscle tissue and affects the sensitivity of myoblasts to insulin.

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SKU: 6367119225

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Amazon Customer
Fort Morgan, US
★★★★★ 5
Impressed!
Color: 02 - Untinted (1.7 oz)
Just got back from a week in Florida at Disney World and this sunscreen was fantastic. I have spent hours researching different products, reading reviews and trying different things and decided to try this on my mature, acne prone skin. I applied it in the morning before leaving the hotel and once more in the middle of the day and it protected my skin from the extreme heat and sun and did not cause any breakouts. It did not run and does not cause a white cast. I would highly recommend this product!
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Reviewed in the United States on May 25, 2026
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Veronica JM
Pawtucket, US
★★★★★ 5
A Daily Essential – Lightweight & Fast-Absorbing
Color: 02 - Untinted (1.7 oz)
I've made this my go-to sunscreen and use it every single day. What sets it apart is the texture – it's smooth and applies beautifully without any sticky residue, which is a game-changer for daily wear under makeup or on its own. The absorption is impressively fast. I can apply it in the morning and not feel like I'm waiting around for it to dry down. It sinks in quickly and leaves my skin feeling clean and protected, not weighed down. For sensitive skin, this is exactly what I needed. This is a must-have in my routine. Highly recommend if you're looking for a lightweight, non-sticky sunscreen that actually works.
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Reviewed in the United States on April 9, 2026
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Bubba Fipps
West Palm Beach, US
★★★★★ 5
Good price
Size: 50 Fl Oz (Pack of 1), Scent: Gentle & Mild
Most Amazon basics items are of decent quality and this is no exception. Nothing fancy just a decent hand soap with typical viscosity that will work in just about any dispenser including automatic dispensers. Most importantly it does a good job cleaning the hands without leaving your hands all sticky and gooey after washing. Yeah. That really is a thing. I've used hand soaps that after rinsing and drying your left with "gheco hands" like you can pick up a penny with your knuckle. No chemical or overpowering odor. One odd thing. The original order came in a box that looked like the Amazon loader threw it into the back of the van from about 50 feet away .... The bottles cap was destroyed and the soap had leaked into the box. Amazon quickly replaced the item with a new bottle no charge and didn't expect me to return the damaged bottle of course. Thing is the second box came in the same condition. Looked like the punter for the Ravens drop kicked it from the 30 into the back of the truck. Luckily the bottle was undamaged this time.
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Reviewed in the United States on April 11, 2026
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Samantha Meyer
Massapequa, US
★★★★★ 5
Convenient refill that lasts a long time
Size: 50 Fl Oz (Pack of 1), Scent: Gentle & Mild
I bought this hand soap refill to save money and reduce plastic waste, and overall I’ve been very pleased with it. The soap has a pleasant scent that isn’t too strong, and it leaves my hands feeling clean without making them feel dry afterward. I also like how easy it is to refill existing dispensers instead of constantly buying new bottles. The large refill size lasts much longer than expected, which is convenient for a busy household. However, pouring the soap into smaller dispensers can be a little messy if you’re not careful. The packaging is somewhat bulky as well. Overall, it’s an economical and practical option that works very well for everyday hand washing.
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Reviewed in the United States on May 25, 2026
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Tony
Lexington, US
★★★★★ 5
Great product at even greater price!
Size: 50 Fl Oz (Pack of 2), Scent: Milk & Honey
This hand soap works very well, has a great scent, and costs less than half of inferior national brands. I have purchased 4 large refill bottles so far.
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Reviewed in the United States on May 29, 2026

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