SKU: 70186842798

HVEM/TNFRSF14 His Tag Protein, Human

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Description

HVEM/TNFRSF14 His Tag Protein, HumanProduct Specification Species Human Synonyms TNFRSF14,ATAR, HVEA, LIGHTR, TR2, CD270 Accession Q92956 1 Amino Acid Sequence Leu39 Val202, with C terminal His Expression System HEK293 Molecular Weight 30 43kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms TNFRSF14,ATAR, HVEA, LIGHTR, TR2, CD270
Accession Q92956-1
Amino Acid Sequence Leu39-Val202, with C-terminal His
Expression System HEK293
Molecular Weight

30-43kDa (Reducing)

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Steinberg MW, et al. (2008) A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med. 205(6): 1463-76. 

2.Pasero C, et al. (2009) A role for HVEM, but not lymphotoxin-beta receptor, in LIGHT-induced tumor cell death and chemokine production. Eur J Immunol. 39(9): 2502-14.

Background

Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily.It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.

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SKU: 70186842798

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4.8 ★★★★★
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Madison G
Pawtucket, US
★★★★★ 5
Perfect for light/moderate chewers
Size: Extra Small, Color: Blue, Size: Extra Small, Color: Blue
My dog wouldn’t stop biting on the toddlers plastic dinosaur toys, so I got him this because it’s similar to plastic. But not hard enough to where it could damage his gums, also not soft enough to break apart. It’s perfect and he’s very happy with it. My dog is 6 LB toy poodle for reference, I would say this is suitable for small dogs. I saw reviews saying that their dog absolutely destroyed it immediately, but then in the review pictures their dogs were baby bulldogs/german shepards! This isn’t meant for breeds like that, but if you have a smaller dog with smaller teeth then this is ideal.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 2, 2026
K
Verified Purchase
Kayann
Lowell, US
★★★★★ 5
Quality and long lasting
Size: Extra Small (Pack of 2), Color: Blue
Highly Recommended!!! My 9 Shihtzu’s absolutely love the smell the durability and taste their thick so last long Thankfully I have to buy these every month!!!
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Reviewed in the United States on January 25, 2026
K
Verified Purchase
Kindle Customer
Chelsea, US
★★★★★ 4
Is this safe for my dog if she chews off little pieces.
Size: Small/Medium, Color: yellow
My Chihuahua loves this, however I want to know is it safe for my dog to swallow? She chews on it and gets little pieces of it and swallows them.
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Reviewed in the United States on June 4, 2026
V
Verified Purchase
Valarie Amundsen
Massapequa, US
★★★★★ 5
Chews
Size: Extra Small, Color: Blue
Chewy toys to keep my dogs, teeth, healthy very important. This was a very good price and I highly recommend buying it for your puppy.
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Reviewed in the United States on June 11, 2026
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Verified Purchase
Judy
Los Angeles, US
★★★★★ 3
Dog likes some
Size: Extra Small, Color: Blue
Puppy will chew on this but not favorite. Over time it gets sharp pieces and dog could ingest. Not sure how safe for a small dog. Affordable but not long lasting.
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Reviewed in the United States on March 30, 2026

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