Pay in installments of $69.60 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 25 - Aug 30
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
KIR2DL5/CD158f Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CD158f Accession Q8N109 Amino Acid Sequence His22 His240, with C terminal Human IgG1 Fc Expression System HEK293 Molecular Weight 60 72kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | CD158f |
| Accession | Q8N109 |
| Amino Acid Sequence | His22-His240, with C-terminal Human IgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 60-72kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Estefania, E. et al. (2007) J. Immunol. 178:4402. 2.Lanier, L. L. (2005) Annu. Rev. Immunol. 23:225. |
Background
Killer cell immunoglobulin-like receptor 2DL5(KIR2DL5), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells.KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells to sense self-HLA.KIR2DL5 is encoded by two paralogous genes displaying copy number variation and allelic polymorphism-KIR2DL5A and KIR2DL5B. Functional polymorphisms in both its promoter and its coding regions are critical for understanding the KIR2DL5 role in immunity and its importance for human health.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.6 ★★★★★
Based on 28 reviews
Sort
Product Reviews
★★★★★ 5
Great for chewers
Size: Large
I have bought these for the dogs (GSD/Husky/Golden) 4 mon-7yrs. All 4 dogs enjoy them and keeps the 2 puppies from chewing things they should not. Definitely worth the money for how long they have lasted as well. Have already ordered more.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 4, 2025
★★★★★ 1
Not as safe as it seems
Size: Xtra Large
I did like the look and sound of the all natural wood and coconut rope. However after 15 minutes of giving it to my dog there were rope fibers everywhere. Even though my research said coconut rope was ok for dogs in small amounts; my dog started throwing up. My cat also managed to get ahold of some of the strings and ended up choking. Even when I took the rope off and gave just the coffee wood stick; after just a few minutes of play my dog began coughing. This is just the experience that I had. All dogs are different. Just please don’t let your best friend play with it unsupervised
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 3, 2025
★★★★★ 5
Best chew toy for a small dog
My Pomchi puppy was chewing on anything and everything, including me. He had a million other toys that he just didn’t care about. This is small and perfect for his tiny, ferocious mouth. It seems very durable so far and believe me, he doesn’t go easy on this thing. It’s hard enough that I can tell it feels good on his tiny, razor sharp teeth. The bone keeps him busy all throughout the day, and it doesn’t squeak, which is good because squeaky toys freak him out. I highly recommend this if you have a tiny, teething monster.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 27, 2025
★★★★★ 5
Pomeranian perfect size
Small size perfect Pomeranian (1 yr old) she prefers over other chews - have ordered twice
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 10, 2026
★★★★★ 5
My puppies favorite bone to chew
I’ve bought at least a half a dozen of puppy bones for my doggie to try, the majority being from Nylabone, and the others from hartz. Her first bone was a pink puppy Nylabone xsmall sise. She definitely must have liked that one but unfortunately I felt like I had to take it away from her too soon, she was teething more then, but even so, thought it was unsafe when I saw little pieces come off and her trying to chew them.
I really like these the best, though I don’t think I’ll be ordering any more at least not until she finishes her new ones. I don’t know what flavor she likes more, it might even be a color thing, but I think she prefers the orange ones which are peanut butter flavored. These are really ideal for toy breeds. My pup is still growing, she’s almost 7 months now, but unsure when she will stop growing, for reference she is a chocolate sable yorkiepoo, not sure of how much she weighs right now, but would estimate she weighs around 5.5-6 pounds. These are perfect for her, and I feel like they out live the other ones I’ve gotten, or she just has more interest in them. I bought a second package on subscribe and save (or possibly on my first and forgot I had a new order and didn’t return), but didn’t open the new package until recently as I felt the first pack were starting to look a bit knawed off, but in the middle there was still plenty of chew left. Oddly, she has prefered the old orange one vs the brand new orange one despite them being the exact same toy and flavor. I think she just hasn’t broken it in yet and I overloaded her with too many toys! I also got them for a great price, for some reason I noticed that the price increased nearly double of what I paid, and now they habe decreased a bit but still are about $2 more than what I paid. She loves all toys, and has many plush kinds. She still teeths, so when she is extra hyper and such, I feel like the bone helps occupy her for a moment. All in all I’d reccomend these out of any puppy bones to chew for toy breeds!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 2, 2022