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Description
Alexa Fluor® 488 Rabbit Anti-Human CD24 Antibody (S-974-13)Product Specification Host Rabbit Antigen CD24 Synonyms Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24A Immunogen Recombinant Protein Location Cell membrane Accession P25063 Clone Number S 974 13 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0.
Product Specification
| Host | Rabbit |
| Antigen | CD24 |
| Synonyms | Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24A |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P25063 |
| Clone Number | S-974-13 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD24 is a highly glycosylated cell surface protein that is anchored to the cell membrane via a glycosyl-phosphatidylinositol (GPI) anchor. It is widely expressed in various cell types, including hematopoietic cells such as B cells, T cells, granulocytes, dendritic cells, and macrophages, as well as non-hematopoietic cells like keratinocytes and neurons. CD24 plays a crucial role in immune cell maturation and regulation of immune responses. In cancer, CD24 is overexpressed on tumor cells and interacts with the inhibitory receptor Siglec-10 on immune cells, helping tumor cells evade immune detection and attack. This interaction has led to its exploration as a potential target for cancer immunotherapy, with promising results from clinical trials of monoclonal antibodies and other targeted therapies.
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