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Description
MLKL Recombinant Rat mAb (SDT-R195)Product Specification Host Rat Antigen MLKL Synonyms Mixed lineage kinase domain like protein, hMLKL Immunogen N A Location Cytoplasm, Nucleus, Membrane, Cell membrane Accession Q8NB16 Clone Number SDT R195 Antibody Type Rat mAb Isotype IgG1 Application WB, ICC Reactivity Hu, Ms, Rt Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability
Product Specification
| Host | Rat |
| Antigen | MLKL |
| Synonyms | Mixed lineage kinase domain-like protein, hMLKL |
| Immunogen | N/A |
| Location | Cytoplasm, Nucleus, Membrane, Cell membrane |
| Accession | Q8NB16 |
| Clone Number | SDT-R195 |
| Antibody Type | Rat mAb |
| Isotype | IgG1 |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| ICC | 1:50 | null |
Background
Mixed lineage kinase domain-like (MLKL) is the executioner in the caspase-independent form of programmed cell death called necroptosis. Receptor-interacting serine/threonine protein kinase 3 (RIPK3) phosphorylates MLKL, triggering MLKL oligomerization, membrane translocation and membrane disruption [PMID: 34698396].
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