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Description
PTP1B Recombinant Rabbit mAb (S-R336)Product Specification Host Rabbit Antigen PTP1B Synonyms Tyrosine protein phosphatase non receptor type 1, Protein tyrosine phosphatase 1B, PTPN1 Location Endoplasmic reticulum membrane Accession P18031 Clone Number S R336 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA,
Product Specification
| Host | Rabbit |
| Antigen | PTP1B |
| Synonyms | Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTPN1 |
| Location | Endoplasmic reticulum membrane |
| Accession | P18031 |
| Clone Number | S-R336 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC-P | 1:250 | null |
Background
PTP1B was first isolated from a human placental protein extract, but it is expressed in many tissues. It is localized to the cytoplasmic face of the endoplasmic reticulum. PTP1B can dephosphorylate the phosphotyrosine residues of the activated insulin receptor kinase. PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes. It has also been implicated in the development of breast cancer and has been explored as a potential therapeutic target in that avenue as well.
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