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Description
Alexa Fluor® 488 Rat Anti-Mouse CD45RA Antibody (S-R564)Product Specification Host Rat Antigen CD45R B220 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); Lymphocyte antigen 5 (Ly 5); T200; CD45; Ly 5; Ptprc Location Cell membrane, Synapse Accession P06800 Clone Number S R564 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical
Product Specification
| Host | Rat |
| Antigen | CD45R/B220 |
| Synonyms | Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); Lymphocyte antigen 5 (Ly-5); T200; CD45; Ly-5; Ptprc |
| Location | Cell membrane, Synapse |
| Accession | P06800 |
| Clone Number | S-R564 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD45RA is an isoform of CD45 (leukocyte common antigen), with a molecular weight of approximately 220kDa or 180kDa (the specific value may vary depending on different studies or measurement methods). This protein is primarily expressed on B cells, monocytes, and a small subset of T cells. In T cells, CD45RA plays a crucial role in regulating immune receptor signaling pathways, modulating T cell activation and suppression. In NK cells, CD45RA is essential for the exertion of cytotoxicity. In the thymus, the expression of CD45RA increases as T cells mature, regulating the transition from naive T cells to mature T cells. Additionally, the protein encoded by the CD45RA gene possesses dephosphorylating activity, which can affect the proliferation, differentiation, and activation of immune cells. In medical applications, CD45RA is used in combination with other B-cell antibodies for the study of B-cell lymphomas. It also plays a key role in the diagnosis of diseases such as acute lymphocytic leukemia and aplastic anemia.
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