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Description
Phospho-STING (Ser366) Recombinant Rabbit mAb (S-2243-62)Product Specification Host Rabbit Antigen Phospho STING (Ser366) Synonyms Stimulator of interferon genes protein; hSTING; Endoplasmic reticulum interferon stimulator (ERIS); Mediator of IRF3 activation (hMITA); Transmembrane protein 173; ERIS; MITA s; STING s; TMEM173; STING1 Immunogen Synthetic Peptide Location Cytoplasm, Lysosome, Mitochondrion, Cell membrane, Endoplasmic reticulum Accession Q86WV6 Clone Number S 2243 62 Antibody Type Recombinant
Product Specification
| Host | Rabbit |
| Antigen | Phospho-STING (Ser366) |
| Synonyms | Stimulator of interferon genes protein; hSTING; Endoplasmic reticulum interferon stimulator (ERIS); Mediator of IRF3 activation (hMITA); Transmembrane protein 173; ERIS; MITA s; STING s; TMEM173; STING1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Lysosome, Mitochondrion, Cell membrane, Endoplasmic reticulum |
| Accession | Q86WV6 |
| Clone Number | S-2243-62 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000-1:2000 | Hu |
Background
Phospho-STING (Ser366) protein is a phosphorylated form of the stimulator of interferon genes (STING) protein, specifically phosphorylated at serine 366. STING is a key component of the innate immune system, playing a crucial role in the cytosolic DNA sensing pathway. When phosphorylated at Ser366, STING is activated and promotes the production of type I interferons and other pro-inflammatory cytokines in response to pathogen-associated molecular patterns or DNA damage. This phosphorylation event is essential for the downstream signaling cascade that leads to the activation of immune cells and the initiation of an antiviral or antibacterial response. Abnormal regulation of Phospho-STING (Ser366) has been implicated in various immune-related diseases, making it a potential target for therapeutic interventions.
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